Developmental Adaptation: Child Health Research Center

描述（由申请人提供）：目前的提案寻求更新耶鲁大学医学院儿科系的耶鲁儿童健康研究职业发展计划（YCHRCDP）。在过去的19年里，YCHRCDP最初是作为P30奖从1990年到2000年的资助，促进了44名研究儿童疾病基本过程的医生科学家的职业发展。我们的长期目标仍然是通过选择优秀的医生科学家，并为他们的独立研究事业做好准备，专注于基础科学研究，从而推进儿童健康研究。像许多没有专门研究基金或私人研究基金会的部门一样，YCHRCDP的支持对于发展一支在基础科学研究方面杰出的教师队伍至关重要。同样值得注意的是，耶鲁儿科没有其他K12项目可以支持初级教师、医生和科学家在基础科学研究方面的培训。69%的学者（42名YCHRCDP毕业生中的72%）获得了NIH的支持，其中57%获得了“R”、“U”或“P”奖助金，这反映了我们项目的成功。59%的学者（占YCHRCDP毕业生的62%）获得了基金会的支持。本资助期内获得K奖的学者比例（88%）超过了90-05年度的K奖比例（44%）。女性占YCHRCDP学者的41%；11%的获奖者是未被充分代表的少数族裔。在获得耶鲁大学K奖的YCHRCDP学者中（19名男性和4名女性），有两名女性获得R-01奖，并且都获得了多次更新。我们的毕业生中有7人现在是耶鲁大学的高级教员（教授或副教授）。在其他院校的23名毕业生中，教授3人，副教授5人，助理教授9人，各系兼职教师6人。我们的学者共发表了719篇科学报告。在过去的5年里，仅报告就有268起。儿科主席Margaret K. Hostetter博士是该提案的首席研究员。Scott Rivkees博士，耶鲁儿童健康研究中心（YCHRC）主任，是一个独立的儿科研究单位，是项目主任（PD）和培训主任（TD）。Alda Tufro医生是儿科肾病科主任，在同事培训方面具有相当的专业知识，她将担任招募官（RO）。她还将重点关注该项目招募女性和代表性不足的少数族裔。在下一个奖项期间，我们将利用我们项目的优势和传统，吸引有才华的医生，培养这些年轻的科学家，让他们在儿童健康方面发展出国家认可的、独立的基础研究项目。根据RFA，所有学者将至少有75%的时间用于研究，研究活动将是基础科学或具有基础科学成分的转化研究。为了实现这些目标，我们在应用程序中详细说明：2.项目管理咨询委员会4.师资力量职业发展计划建议6.项目评估考生/学者制度环境和对项目的承诺加强多样性的招聘和保留计划负责任的研究行为指导。总的来说，上述项目将继续并改进我们培养内科科学家从事基础科学研究的传统，以改善儿童健康。与过去一样，我们将在下一个拟议的奖项期限内继续加强YCHRCDP。

DESCRIPTION (provided by applicant): The current proposal seeks renewal of the Yale Child Health Research Career Development Program (YCHRCDP) in the Department of Pediatrics at Yale University School of Medicine. Initially funded as a P30 award from 1990-2000, over the past 19 years the YCHRCDP has fostered the career development of 44 physician-scientists studying fundamental processes of childhood disease. Our long-term goal continues to be the advancement of research in child health by selecting outstanding physician-scientists and preparing them for independent research careers, focusing on basic science research. Like many departments without a dedicated research endowment or a private research foundation, the support of the YCHRCDP has been critical and essential to developing a faculty distinguished in basic scientific investigation. It is also important to note that no other K12 programs are available to Yale Pediatrics that support junior faculty, physician-scientist training in basic science research. Reflecting the success of our program, 69% of all Scholars (72% of the 42 YCHRCDP graduates) have received NIH support, with 57% receiving 'R', 'U', or 'P' grants. 59% of all Scholars (62% of YCHRCDP graduates) have received foundation support. The percentage of Scholars receiving K awards during the current funding period (88%) exceeds the K award percentage of Scholars from 90-05 (44%). Women comprise 41% of YCHRCDP Scholars; 11% of awardees are underrepresented minorities. Of those YCHRCDP Scholars who have completed K awards at Yale (19 males and 4 females), two females attained R-01 awards and both have renewed multiple times. Seven of our graduates are now senior faculty members (Professor or Associate Professor) at Yale. Of the 23 YCHRCDP graduates at other institutions, 3 are Professors, 5 are Associate Professors, 9 are Assistant Professors, and 6 are adjunct faculty in various departments. Collectively our scholars have published 719 scientific reports. Over the past 5 years, there have been 268 reports alone. Dr. Margaret K. Hostetter, Chair of Pediatrics, is the Principal Investigator (PI) of this proposal. Dr. Scott Rivkees, Director of the Yale Child Health Research Center (YCHRC), a free- standing pediatric research unit, is the Program Director (PD) and Training Director (TD). Dr. Alda Tufro, who is Chief of Pediatric Nephrology and has considerable expertise in fellow training, will be the recruiting officer (RO). She will also focus on the recruitment of women and underrepresented minorities to the program. Over the next term of award, we will build on the strengths and traditions of our program to attract talented physicians and to nurture these young scientists as they develop nationally recognized, independent basic research programs in child health. Per the RFA, all Scholars will have at least 75% of their time devoted to research, and research activities will be in basic science or translational research with a basic science component. To achieve these goals, in the application we detail: 1. Program Administration 2. Advisory Boards 3. Program Faculty 4. Proposed Career Development Plan 5. Program Evaluation 6. Candidates/ Scholars 7. Institutional Environment and Commitment to the Program 8. Recruitment and Retention Plan to Enhance Diversity 9. Instruction in the Responsible Conduct of Research. Collectively, the above programs will continue and improve upon our tradition of training physician scientists for careers in basic science research for the betterment of child health. As in the past, we will continue to enhance the YCHRCDP over the next proposed term of the award.