Cancer Biology Training Grant

描述（由申请人提供）：这个博士前和博士后培训项目强调从实验室到床边的研究，包括最先进的癌症研究领域。除了癌症研究的基础知识和合理的科学理论，学生和博士后将在癌症研究的许多基础领域接受培训，包括使用高通量化学和遗传筛选来定义细胞网络的药物发现，信号转导途径，DNA损伤和修复反应，以及使用细胞和动物分子成像的纳米医学靶向治疗药物递送。21世纪的癌症问题仍然是国家优先考虑的问题，因此，为培养博士预科和博士后学生提供了实质性的长期职业机会。我们的培训计划的目标是：(a)培养能够进行独立癌症研究的高素质科学家；(b)培养在今天和将来的学术或工业领域取得成功所需的智力、技术和沟通技巧；(c)提供对人类癌症的基本、公共卫生和临床问题的理解。这项培训资助的能力是将基础科学学院现有的优秀基础与我们在Harold Simmons NCI指定癌症中心的癌症生物学和治疗项目相结合，将其与标准化的普通研究生和研究生教育项目区分开来。我们有43名教师培训师，代表西南大学24个不同的部门和中心。我们组建了一个由指导委员会成员组成的专门小组，并得到了癌症中心主任的行政支持和智力和财政支持。我们为博士前和博士后受训者制定了一个综合的癌症培训计划，详细说明了癌症教育和培训的所有关键步骤，包括生物医学伦理、负责任的科学行为、生物统计学、生物信息学和数据共享。我们有一个具体的项目计划，以招聘和留住地域范围广泛的博士预科和博士后申请者，以及代表性不足的多元化学员。我们已经扩展并实施了我们的癌症教学和期刊导向课程，包括基础课程和转化课程。在过去的四年里，我们国内符合条件的博士前和博士后申请人数几乎翻了一番，我们的教师培训师人数增加了大约50%。

DESCRIPTION (provided by applicant): This predoctoral and postdoctoral training program emphasizes bench to bedside research encompassing state-of-the-art areas of cancer research. Along with training in the fundamentals of cancer research and sound scientific theory, students and postdoctoral fellows will be trained in many fundamental areas of cancer research including, drug discovery using high throughput chemical and genetic screens to define cellular networks, signal transduction pathways, DNA damage and repair responses, and nanomedicine-targeted therapeutic drug delivery using cell and animal molecular imaging. The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for the training of predoctoral and postdoctoral students. The goals of our training program are to (a) train top-quality scientists capable of conducting independent cancer research; (b) foster the intellectual, technical, and communication skills required to succeed in the academic or industrial arenas of today and in the future; and (c) provide an understanding of the basic, public health, and clinical problems of human cancer. The ability of this training grant to bridge an existing outstanding foundation of Faculty in Basic Science with our Cancer Biology and Therapy Programs in the Harold Simmons NCI Designated Cancer Center, distinguishes it from a standardized general graduate and post-graduate educational program. We have 43 committed Faculty Trainers representing 24 different Departments and Centers at UT Southwestern. We have assembled a dedicated group of Steering Committee members, along with Administrative Support and both intellectual and financial support from the Director of the Cancer Center. We have an integrated plan for the proposed Cancer Training Program for both predoctoral and postdoctoral trainees that details all key steps in cancer education and training, including biomedical ethics, the responsible conduct of science, biostatistics, bioinformatics, and data sharing. We have a program specific plan for recruiting and retaining a geographically broad range of predoctoral and postdoctoral applicants as well as underrepresented diversity trainees. We have expanded and implemented our cancer didactic and journal oriented courses, both basic and translational. Our domestic eligible predoctoral and postdoctoral applicant pool has almost doubled during the last 4 years and our Faculty Trainer pool has increased by approximately 50%.