NICHD Cooperative Multicenter Neonatal Research Network

描述(由申请人提供)：爱荷华大学提交续签申请，以继续参加NICHD合作多中心新生儿研究网络(RFA-HD-10-003)。我们为该网络提供了五个特别的优势。1.我们的NICU的临床结果是一流的--在世界上名列前茅。我们的极低出生体重儿死亡率在新生儿研究网络中一直是最低的。由于我们的低死亡率和高随访率，我们看到与一些更大的网络中心一样多的极低出生体重儿在随访中。2.在新生儿和婴儿的临床研究方面，我们有着深厚的传统和重要贡献的记录。在产科和NICU，我们拥有强大的基础设施来进行和支持临床研究，这对我们的生产力做出了贡献。3.我们在遗传学领域拥有相当多的专门知识和资源，包括我们于1999年建立的围产期研究DNA资料库。我们的DNA库和其他机构的样本正被用于研究新生儿疾病的遗传影响。在我们加入网络的头5年里，我们的一名研究人员Jeff Murray博士与网络中的其他人合作，在网络范围内应用遗传学和基因组学方法，包括开发未来DNA存储库的应用程序。4.作为一个以农村为主、经济以农业为基础的州唯一的学术医疗中心，我们代表的人口在NICHD网络中没有得到很好的代表。如果网络研究的结果要推广到全国的患者，就应该代表这个国家的这一大片地区。爱荷华大学网络中心代表着这个地区和人口。5.在过去的5年里，我们作为网络中心的表现非常好。在本供资周期中提交的新项目中，我们大约贡献了六分之一。我们的ELBW死亡率是该网络中最低的，我们的死亡或神经发育障碍的综合结果的比率也是最低的。我们的随访率是网络中最高的之一。自今年年初我们增加了第二个网站以来，我们在通用数据库中的患者注册人数增加了一倍多。

DESCRIPTION (provided by applicant): The University of lowa submits this renewal application for continued participation in the NICHD Cooperative Multicenter Neonatal Research Network (RFA-HD-10-003). We offer five special strengths to the Network. 1. Our NICU's clinical outcomes are superb - among the best in the world. Our VLBW mortality is perennially the lowest in the Neonatal Research Network. With our low mortality and high follow-up rate, we see as many as VLBW infants in follow-up as some much larger Network centers. 2. We have a strong tradition and track record of important contributions in clinical research in neonates and infants. In the obstetrics units and the NICU, we have a robust infrastructure for the conduct and support of clinical research that has contributed to our productivity. 3. We have considerable expertise and resources in the area of genetics, including our Perinatal Research DNA Bank, which was created in 1999. Samples from our DNA Bank and others are being used for research on the genetic influences of neonatal disease. During our first 5 years in the Network, one of our investigators, Dr. Jeff Murray, has worked with others in the Network to apply genetics and genomics approaches on a Network-wide scale, including the application to develop a prospective DNA repository. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of lowa Network center represents this region and population. 5. We have performed extremely well as a Network center during the past 5 years. We have contributed approximately 1/6 of the new projects submitted in the current funding cycle. Our ELBW mortality rates are the lowest in the Network, and we have the lowest rate of the composite outcome of death or neurodevelopmental impairment. Our follow-up rate is among the highest in the Network. Our patient enrollment in the Generic Database has more than doubled since we added a second site early this year.