Cancer Cell Biology Training Program

描述(申请人提供)：在过去几十年的研究中，我们在了解癌症的遗传基础以及驱动癌症进展和恶性生长的异常信号成分和机制方面取得了令人印象深刻的进展。近年来，人类和最近多个癌细胞基因组测序的完成，加上癌细胞全基因组遗传、细胞和生化图谱技术的快速发展，极大地加速了这些进展。这一步伐在未来肯定会成倍加快。新信息的积累既令人印象深刻，也令人望而生畏。因此，下一个十年的主要挑战将是将基础癌症研究进展转化为新的分子靶向癌症疗法。癌症细胞生物学培训计划(CCBTP)的前提是，癌症生物学是一门独特的、跨学科的生物医学科学，包括细胞生物学、分子生物学、生物化学、遗传学、免疫学、微生物学、药理学、流行病学、毒理学、病理学和生理学的实验方法和教学知识。博士生将从更传统的以系或课程为基础的培训计划中，在分子和细胞生物学的范例方面得到很好的培训。他们很少会在癌症的病理生物学和治疗方面接受重要的培训。随着对多学科、转化性、以疾病为导向的研究的日益重视，解决研究生培训中这一不足的必要性变得更加紧迫。因此，这个项目的广泛目标是提供翻译癌症生物学的全面培训，使学生能够有效地为新一轮的翻译研究做出贡献。CCBTP非常强调癌症的组织病理学，以及对肿瘤生物学至关重要的其他主题的接触，特别是个性化药物和分子靶向抗癌药物的发现和开发。因此，它促进了对受过独特培训的博士生的培训，这些博士生明显有别于由北卡罗来纳大学教堂山分校的国家卫生研究院资助的个别部门或其他培训项目的博士生

DESCRIPTION (provided by applicant): Research during the past several decades has made impressive advances in our understanding of the genetic basis of cancer and the aberrant signaling components and mechanisms that drive cancer progression and malignant growth. In recent years, the completion of the sequencing of the human and more recently, of multiple cancer cell genomes, coupled with the rapid development of technologies for the genome-wide genetic, cellular and biochemical profiling of the cancer cell has greatly accelerated these advances. This pace will surely be accelerated exponentially in the future. The accumulation of new information is both impressive and daunting. Therefore, a major challenge of the next decade will be to translate basic cancer research advances into new molecularly targeted cancer therapies. The premise of the Cancer Cell Biology Training Program (CCBTP) is that cancer biology is a unique, interdisciplinary biomedical science that encompasses experimental approaches and didactic knowledge from cell biology, molecular biology, biochemistry, genetics, immunology, microbiology, pharmacology, epidemiology, toxicology, pathology, and physiology. Doctoral students will become well-trained in the paradigms of molecular and cellular biology from more traditional department- or curriculum-based training programs. Rarely will they receive significant training in the pathobiology and treatment of cancer. With an increasing emphasis on multidisciplinary, translational, disease-oriented research, the need to address this deficiency in graduate student training has become of greater urgency. Thus, the broad goal of this program is to provide comprehensive training in translational cancer biology to allow students to effectively contribute to the new wave of translational research. The CCBTP provides a strong emphasis on the histopathology of cancer and exposure to other topics crucial to tumor biology, in particular personalized medicine and molecularly targeted anti-cancer drug discovery and development. Therefore, it fosters the training of doctoral candidates who are uniquely trained and who are clearly distinguished from those of individual departments or other training programs funded by the National Institutes of Health at the University of North Carolina at Chapel Hill