CSHL 2014 Mechanisms and Models of Cancer Conference

描述（由申请人提供）：冷泉港实验室会议机制和癌症模型2014年8月12日至16日近年来已经产生了变革性的发现，揭示了癌症发展和进展背后的机制，并基于这些发现在临床上实施靶向癌症治疗。总的来说，这些进展正在改善癌症患者的生活质量和总体生存率。有惊人的技术发展，我们现在可以利用它来询问癌症基因组和表观基因组，并检查肿瘤干细胞，异质性和转移的出现。我们可以在体内随意打开或关闭癌基因和肿瘤抑制基因，以确定它们的功能，检查致癌蛋白的三维结构，开发小分子抑制剂或拮抗抗体，并可以可视化癌细胞参与的代谢途径。在这个快速发展的领域，这些技术、模型和基于机制的方法的传播和使用得到了会议的极大促进，这些会议将研究人员聚集在一起，介绍并公开讨论他们最新的未发表的研究结果。我们还需要培训该领域的下一代领导者，其中一个重要部分是为年轻的研究人员提供绝佳的机会，如研究生和博士后，展示他们的工作并与高级研究人员进行一对一的互动。在冷泉港实验室（CSHL）举行的癌症机制和模型会议是实现癌症研究下一个智力飞跃的最佳工具之一，并将该领域推向未来，以造福癌症患者。各次会议的确切范围将根据公开提交的摘要决定。每场会议将由该领域的两名知名科学家主持，包括组织者，他们将根据提交的摘要确定每场会议的形式。各位主席将介绍并概述各自会议的议题。将特别注意鼓励研究生、博士后研究员和新的研究人员积极参与，并鼓励该领域的主要科学家参加。两位癌症遗传学不同领域的领先专家将在会议期间发表主题演讲。预计这次会议将为不同研究领域的初级和高级研究人员交流数据和想法提供独特的机会，因为它们适用于癌症遗传学和肿瘤抑制基因。鉴于1996年至2012年期间在CSHL举行的关于这一主题的会议取得了成功，我们预计将有来自世界各地实验室的约400名科学家出席。

DESCRIPTION (provided by applicant): COLD SPRING HARBOR LABORATORY CONFERENCE MECHANISMS AND MODELS OF CANCER August 12 - 16, 2014 Recent years have produced transformative discoveries revealing the mechanisms behind the development and progression of cancer and the implementation of targeted cancer therapies in the clinic based on these discoveries. Collectively these advances are improving both the quality of life and overall survival of cancer patients. There have been stunning technological developments that we now have at our disposal with which to interrogate the cancer genome and epigenome, and examine tumor stem cells, heterogeneity and the emergence of metastasis. We can turn oncogenes and tumor suppressor on an off at will in vivo to determine their function, examine the three-dimensional structure of oncogenic proteins and develop small molecule inhibitors or antagonistic antibodies, and can visualize the metabolic pathways cancer cells engage. Dissemination and use of these technologies, models and mechanism-based approaches in this fast-moving field is greatly facilitated by meetings that bring investigators together to present and openly discuss their latest unpublished research findings. We also need to train the next generation leaders in the field, and an essential part of that is this fantastic opportunity for young investigators, such as graduate students and postdocs, to present their work and interact one-on-one with senior investigators. This Mechanisms and Models for Cancer meeting at Cold Spring Harbor Laboratory (CSHL) is one of the best vehicles for materializing the next intellectual leaps in cancer research and propelling the field into the futue to the benefit of cancer patients. The precise scope of the individual sessions will be decided on the basis of the openly submitted abstracts. Each session will be chaired by two established scientists in the field including the organizers, who will establish the format of each session based on the submitted abstracts. The chairs will introduce and give an overview of the topics in their sessions. Particular attention will be given to encouraging the active participation of graduate students, postdoctoral fellows and new investigators, as well as the attendance of leading scientists in the field. Two leading experts in diverse areas of cancer genetics will deliver keynote addresses during the conference. It is anticipated that the meeting will provide unique opportunities for the exchange of data and ideas by both junior and senior investigators in different areas of research as they apply to cancer genetics and tumor suppressor genes. Given the success of past meetings held at CSHL on this topic between 1996 and 2012, we anticipate the attendance of about 400 scientists from laboratories around the world.