Drug Dependence Clinical Research Program

描述（由申请人提供）：本核心支持中心拨款（P30）申请要求继续支持分析和合成化学实验室以及管理共享核心基础设施。参与的、目前获得资助的组成项目继续进行滥用药物的临床药理学、药物疗法和其他治疗策略的人体实验室和治疗临床研究项目，以治疗药物滥用和成瘾。参与项目和检测的药物包括尼古丁及其代谢物、可卡因、甲基苯丙胺和其他苯乙胺、酒精、MDMA、麻黄生物碱、咖啡因、γ -羟基丁酸盐（GHB）、salvinorin、腺苷、神经类固醇和鸦片剂。分析方法已经在核心分析实验室开发和验证，以支持这些药物的研究。其他新的测定方法和标记（氘化）化合物将根据需要提供给相关的研究项目。参与项目和研究者代表的学科包括精神病学、临床心理学、神经病学、普通内科、心脏病学和临床药理学、精神药理学、毒理学、遗传学、儿科学、药学、有机化学、药物化学和分析化学、统计学。我们的目标是：(1)为UCSF和其他机构的药物滥用研究人员的参与项目提供最先进的设备和人员，分析和合成化学实验室资源。(2)为价值参与项目的论文准备、IRB及相关规范性文件、经费管理等科研行政服务提供行政支持。(3)为参与项目提供有关研究设计和数据分析策略的统计咨询服务，特别是最佳药代动力学分析。总体目标是提供先进的分析实验室资源，并提供稳定的支持，同时提供足够的行政支持，以响应个别资助的组成科学项目的需求，因为这些项目发生了变化和发展。该设施是一个具有成本效益的共享实验室资源，增强和扩展了目前由NIH或其他联邦或非联邦来源资助的研究人员的研究可能性，以进一步了解人类精神活性药物的使用，滥用和成瘾，其健康后果及其治疗管理。

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects and assays available include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates. Analytical methods have been developed and validated in the core analytic laboratory to support studies with these drugs. Other new assays and labeled (deuterated) compounds will be made available to the associated research projects as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) to provide a state-of-the-art well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative support for manuscript preparation, IRB and related regulatory documents, grants management, and other research administrative services of value participating projects. (3) To provide statistical consulting services regarding study design and data analysis strategies, particularly optimal pharmacokinetic analysis to participating projects. The overall objective is to provide sophisticated analytic laboratory resources with stability of support together with adequate administrative support responsive to the needs of individual funded constituent scientific projects as those projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.