Specialized Cancer Center Support Grant

描述(申请人提供)：加州大学圣迭戈分校(UCSD)摩尔斯癌症中心(MCC)拥有丰富的历史，是NCI指定的综合性癌症中心，目前拥有来自28个UCSD部门的239名成员。经同行审查的MCC资金为1.183亿美元(直接成本)，其中3320万美元来自NCI。来自非同行审查来源的额外1560万美元导致直接费用供资总额为1.339亿美元。我们在资助期间发表了4000多篇以癌症为重点的论文(20%在计划间或计划内；10%在有影响因子的期刊上)。在圣地亚哥/拉霍亚，MCC被其他几家主要的生命科学研究机构和489家生物技术公司包围，这是美国最大的两个生命科学集群。MCC是该地区唯一由NCI指定的综合性癌症中心。MCC利用这一优势通过改变癌症预防、检测和护理(使命)来拯救生命，并使个性化癌症药物成为现实(愿景)。这是我们与合作伙伴圣地亚哥州立大学(SDSU)作为联盟中心首次续签申请，从而正式确立了MCC和SDSU之间长期、富有成效的合作关系。按照设计，MCC大楼1)促进了该中心基础科学、临床科学和人口科学部门的医生和科学家之间的跨学科合作，2)将NCI支持的广泛共享资源聚集在一个公共的、可访问的站点，3)充当圣地亚哥公共和私营部门转化型癌症研究人员的学术和行业中心。绝大多数成员在MCC大楼或加州大学圣地亚哥分校；其他成员在附近的La Jolla学院。这份申请报告了六个研究项目：癌症生物学和信号、癌症基因组和网络、血液恶性肿瘤、实体肿瘤治疗、癌症预防和减少癌症差异。我们还提出了七个共享资源：生物库和组织技术、生物统计学、基因组学和生物信息学、显微镜、流式细胞术、转基因小鼠、饮食和体力活动。所有计划和资源都反映了MCC的科学优势和目标。MCC准备利用其卓越的基础科学和人口科学以及圣地亚哥范围内的合作(学术和私营部门)来开发创新的基于科学的癌症预防和治疗。此应用程序汇总了我们的投资、招聘、协作、组织变更、计划和实现这一目标的进展。 CCSG的资助推动了加州大学摩尔斯癌症中心的使命，即通过改变癌症预防、检测和护理以及使个性化癌症药物成为现实的愿景来拯救生命。癌症中心将基础发现及其转化(通过利用圣地亚哥独特的学术界和工业界环境)转化为减轻癌症负担的重大临床进展，放在最优先的位置。

DESCRIPTION (provided by applicant): The UC San Diego (UCSD) Moores Cancer Center (MCC) has a rich history as a matrix, NCI-designated comprehensive cancer center, now with 239 members from 28 UCSD departments. Peer-reviewed MCC funding is $118.3 million (direct costs), of which $33.2 million is from the NCI. An additional $15.6 million from non-peer-reviewed sources results in total direct-cost funding of $133.9 million. We have published over 4000 cancer-focused papers in the funding period (20% inter- or intra-programmatic; 10% in journals with an impact factor >15). MCC is surrounded by several other major life-science research institutes and 489 biotechnology companies in San Diego/La Jolla, the 2"'' largest life-sciences cluster in the US. MCC is the only NCI-designated comprehensive cancer center in this region. MCC leverages this advantage to save lives by transforming cancer prevention, detection, and care (mission) and to make personalized cancer medicine a reality (vision). This is our first renewal application as a consortium center with partner San Diego State University (SDSU), thus formalizing long-standing, productive collaborations between MCC and SDSU. As designed, the MCC building 1) stimulates interdisciplinary collaboration between physicians and scientists in the Center's Divisions of Basic Science, Clinical Science, and Population Science, 2) assembles the extensive NCI-supported Shared Resources in a common, accessible site, and 3) acts as an academia-industry hub for translational cancer researchers within the public and private sectors of San Diego. The vast majority of members are in the MCC building or on the UCSD campus; others are in nearby La Jolla institutes. This application reports on six Research Programs: Cancer Biology and Signaling, Cancer Genomes and Networks, Hematologic Malignancies, Solid Tumor Therapeutics, Cancer Prevention, and Reducing Cancer Disparities. We also propose seven Shared Resources: Biorepository and Tissue Technology, Biostatistics, Genomics and Bioinformatics, Microscopy, Flow Cytometry, Transgenic Mouse, Diet and Physical Activity. All Programs and Resources reflect the scientific strengths and goals of the MCC. MCC is poised to leverage its exceptional basic and population sciences and San Diego-wide collaborations (academic and private-sector) in developing innovative science-based cancer prevention and treatment. This application summarizes our investments, recruitments, collaborations, organizational changes, plans, and progress toward this goal. CCSG funding advances the UCSD Moores Cancer Center mission to save lives by transforming cancer prevention, detection, and care, and vision to make personalized cancer medicine a reality. The Cancer Center places the highest priority on basic discovery and its translation (via leveraging San Diego's unique academia-industry environment) into major clinical advances that reduce the burden of cancer.