CB1 Receptor PET Imaging Reveals Gender Differencesin PTSD

描述（由申请人提供）：尽管人们普遍认为创伤后应激障碍（PTSD）的患病率和临床病程存在性别差异，但关于PTSD中这些已报道的性别差异的神经生物学机制的数据缺乏；因此，更好地了解神经生物学上的性别差异有可能提供对创伤后应激障碍神经生物学的理解，也将导致改善对男性和女性的干预和服务。我们拟招募N=12名无药物治疗的平民PTSD女性患者，使用PET测量其CB1受体选择性放射配体[11C]OMAR分布体积（VT）， CB1受体表达量的等量，并与12名男性PTSD患者，以及年龄、性别和bmi匹配的有（TC， N=24）和无（HC， N=24）创伤史的对照组进行比较。这将回答这一应用的关键问题，是否存在应激反应在受体水平上的性别差异导致CB1蛋白表达升高的PTSD妇女在PTSD电路。

DESCRIPTION (provided by applicant): Despite the widely acknowledged gender differences in the prevalence and clinical course of posttraumatic stress disorder (PTSD), there exists a paucity of data on the neurobiological mechanisms that explain these reported gender disparities in PTSD; therefore, better understanding of neurobiological sex differences has the potential to provide understanding of the neurobiology of PTSD and will also lead to improving interventions and services for males and females. We propose to recruit N=12 medication-free female patients with civilian PTSD, measure their CB1 receptor-selective radioligand [11C]OMAR volumes of distribution (VT), an equivalent of CB1 receptor expression using PET and compare them with 12 men with PTSD, as well as individually age, gender and BMI-matched controls with (TC, N=24) and without (HC, N=24) trauma history. This will answer the key question of this application if there exist a sex difference in stress responsiveness on a receptor level resultant in elevated CB1 protein expression in PTSD women in a PTSD circuit.