Administrative Core

行政核心将负责本计划的所有行政管理。这里提出的计划包括3个独立但相互关联的项目和2个科学核心，它们将开发3种不同的策略，以交付能够转录抑制HIV-1或CCR5趋化因子共受体的非编码RNA，并将其切除到HIV-1感染的细胞或那些针对HIV-1感染的免疫细胞。行政核心将通过以下方式发挥作用：监督整个项目的财政、行政和法律责任；促进不同调查人员与其各自项目之间的互动；并承担确认所有研究以最佳方式进行的责任 以及合乎道德的态度。因此，行政核心的作用对于这一方案的成功是不可或缺的。 行政核心的具体目标是： (1)协调计划的行政和财政要求。 (2)监督和促进项目的科学进步。 (3)监督计划内每个项目成果的传播和分享。

The administrative core will be responsible for all administration of this program. The program proposed here contains 3 independent yet linked projects and 2 scientific cores that will develop 3 different strategies to deliver non-coding RNAs capable of transcriptionally suppressing and directing the excising of HIV-1 or the CCR5 chemokine co-receptor to either HIV-1 infected cells or those immune cells targeted for infection by HIV-1. The administrative core will function by: Overseeing the fiscal, administrative, and legal responsibilities for the entire program; fostering interactions between the different investigators and their respective projects; and assuming responsibility for confirming that all research is conducted in an optimal and ethical manner. As such the role of the administrative core is integral to the success of this program. The specific aims of the administrative core are: (1) Coordinate administrative and fiscal requirements of the program. (2) Supervise and foster the scientific progress of the program. (3) Oversee the dissemination and sharing of the results from each project within the program.