CSHL 2014 Molecular Chaperones & Stress Response Conference

描述(由申请人提供)：本提案是为2014年4月29日至5月3日在冷泉港实验室举行的分子伴侣和应激反应会议提供部分资金支持的请求。这次会议是介绍这一领域新成果的主要国际形式，来自该领域几乎所有主要实验室的代表都出席了会议。关于蛋白质折叠状态是如何在体内获得和保持的新信息的爆炸性增长，以及这一过程在越来越多的疾病状态和正常衰老中的参与，确保了这次会议的兴奋。由于最近的发展已经确定了新的和新兴的分子机器及其作用机制，将有两个会议致力于蛋白质折叠机器的机械洞察。此外，越来越清楚的是，这些机器不是单独工作的，而是在折叠机网络中协调工作的。因此，我们将第一次举办一场关于蛋白质折叠的网络评估的会议。蛋白质错误折叠和疾病将在会议上得到大量代表，而表明错误折叠导致疾病的蛋白质传播的新兴原则将在其本身的会议上主要展示和讨论。在蛋白质折叠应激期间，细胞为确保分泌途径的完整性而使用的各种蛋白质质量控制策略将被展示，以及细胞内空间质量控制的一个新的新兴话题。热休克蛋白和分子伴侣的领域发展迅速，不仅引起了基础科学中传统科学学科的兴趣，也引起了包括神经退行性疾病、传染病、癌症、心脏病和衰老在内的众多生物医学研究领域的兴趣。会议将包括九个讲座和三个海报会议。拟议的会议包括：1)蛋白质折叠机器，2)蛋白质折叠机器，2，3)蛋白质稳态网络，4)空间质量控制，5)蛋白质错误折叠疾病-传染性传播，6)内质网质量控制，7)蛋白质降解途径，8)蛋白质合成，9)功能聚集。每期会议由8至9名口头陈述组成，由一名特邀发言者主持。每届会议最多只能再邀请两名发言者，其余发言者将从提交的摘要中选出。这种讨论的平衡使会议能够以顶尖科学家的陈述为特色，对令人兴奋的新发展做出反应，鼓励多样化的参与，并表彰新的研究人员。

DESCRIPTION (provided by applicant): This proposal is a request for partial financial support for a meeting on Molecular Chaperones and Stress Responses to be held at Cold Spring Harbor Laboratory from April 29 - May 3, 2014. This meeting is the premier international format for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the involvement of this process in an increasing number of disease states and in normal aging guarantees the excitement of this meeting. Because of the recent developments that have identified new and emerging molecular machines and their mechanism of action, there will be two session devoted to mechanistic insight of protein folding machines. Additionally, it is becoming more clear that these machines do not work in isolation, but are orchestrated in a network of folding machineries. Therefore, for the first time we will have a session devoted to network evaluation of protein folding. Protein misfolding and disease will be heavily represented at the meeting and emerging principles that suggest the spread of misfolded disease causing proteins will be predominantly displayed and discussed in it own session. The diverse protein quality control strategies used by a cell to ensure the integrity of the secretory pathway during times of protein folding stress will be represented as well as a new emerging topic on spatial quality control within a cell. The field of heat shock proteins and molecular chaperones has grown rapidly and draws interest not only from traditional scientific disciplines in the basic sciences but also from numerous areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will include nine lecture sessions and three poster sessions. The proposed sessions include: 1) Protein Folding machines, 2) Protein folding machines 2, 3) Networks of protein homeostasis, 4) Spatial quality control, 5) Protein misfolding diseases - infectious spreading, 6) ER quality control, 7) Protein degradation pathways, 8) Protein synthesis, 9) Functional aggregation. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. A maximum of two additional speakers will be pre-invited per session and the remainder will be selected from submitted abstracts. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators.