Integrated Molecular and Cellular Immunology Core

项目总结(见说明)： 分子和细胞免疫学核心： 埃默里移植中心和该联盟受益于进行非人灵长类(NHP)移植耐受研究的综合方法。这一整合的中心是整合的分子和细胞免疫学核心(MClC)，它协调和简化所有常见的分析和程序，以及ETC所有成员的NHP采购和分型需求。MClC由五个相互作用的元素组成：(1)MHC免疫遗传学和分型核心。(2)流式细胞仪核心。(3)NHP组织病理学核心。(4)分子免疫学和病毒学核心；(5)功能保护性免疫核心。每个核心都满足了开展每个项目中提议的复杂实验的迫切需要，并促进了调查人员之间的合作。因此，这些集成服务的开发显著提高了我们团队能够进行复杂的NHP移植耐受研究的效率和严谨性。

PROJECT SUMMARY (See instructions): The Molecular and Cellular Immunology Core: The Emory Transplant Center and this Consortium benefits from an integrated approach to performing nonhuman primate (NHP) transplant tolerance research. The hub of this integration is the integrated Molecular and Cellular Immunology Core (MClC), which coordinates and streamlines all common assays and procedures, as well as the NHP procurement and typing needs for all members of the ETC. The MClC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core. (2) The Flow Cytometry Core. (3) The NHP Histopathology Core. (4) The Molecular Immunology and Virology Core and (5) The Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.