Antimicrobial Drug Discovery from Coevolved Symbiotic Communities

描述(由申请人提供)： 大型制药公司的抗菌创新已经放缓，而抗菌素耐药感染的流行激增，威胁着公众健康。威斯康星州抗菌药物发现和开发中心的首要目标是开发治疗对策，以应对抗菌素耐药性危机。根据我们的初步数据，我们假设，使用互补和集成的尖端方法对共生环境进行天然产品探索将为抗菌药物的发现提供一个新的范式。该中心提出了创新的概念和技术进步，以克服传统抗微生物药物发现平台中确定的关键瓶颈，从而为耐药流行病提供治疗对策。

DESCRIPTION (provided by applicant): Antimicrobial innovation by Big Pharma has slowed to a crawl while an epidemic of antimicrobial-resistant infections surges, threatening the public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. Based upon our preliminary data, we hypothesize that natural product exploration of symbiotic environments using complementary and integrated cutting-edge approaches will provide a new paradigm for antimicrobial drug discovery. The Center proposes innovative conceptual and technical advances to overcome critical bottlenecks identified in traditional antimicrobial drug discovery platforms to deliver therapeutic countermeasures for the drug-resistance epidemic.