Clinical Research Core

项目摘要(见说明)：维克森林大学老年美国人独立中心(WFU OAIC)的临床研究核心(CRC-资源核心1)提供了成功进行专注于老年人身体功能和残疾的临床研究所必需的关键基础设施和研究人员资源。CRC与其他OAIC资源核心(生物成像、综合生物学和生物统计核心)很好地结合在一起。与他们一起，儿童权利委员会将支持外部资助的研究、OALC资助的试点和研究开发项目，以及与WFU OAIC研究主题有关的其他外部资助项目：将影响身体功能的途径整合到残疾治疗和预防的新方法中。CRC的优先事项将是支持将基础研究发现转化为人类人口研究的临床试验；针对老年人身体功能和残疾的骨质疏松症和肥胖相关的临床研究；以及与这些风险因素相关的新干预措施的试验。CRC还将协助领导力和行政核心(LAC)、试点和探索性研究核心(PESC)和研究职业发展核心(RCDC)确定有前途的新研究人员和项目，以帮助解决身体残疾的机制和预防。CRC将提供对成功的临床研究至关重要的“交钥匙”资源，包括：1)与实验研究设计和实施相关的专业知识，包括选择适当的结果衡量标准；2)高效和有效的参与者招募3)标准化的身体功能评估单元；4)采购(与综合生物学核心一起)肌肉和脂肪组织和血液样本；5)维护(与生物统计核心协调)统一的结果数据库；6)协助初级调查人员处理IRB和其他监管文件(与PESC和RCDC协调)。在目前的周期中，这些关键资源的提供对于我们及时完成临床研究、发布结果、竞争新的独立资助的拨款以及发展新的研究人员是不可或缺的。

PROJECT SUMMARY (See instructions): The Clinical Research Core (CRC - Resource Core 1) of the Wake Forest University Older Americans Independence Center (WFU OAIC) provides the critical infrastructure and investigator resources essential to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Biolmaging, Integrative Biology and Biostatistics Cores). With them, the CRC will support externally funded studies, OAlC-funded Pilot and Research Development Projects, and other externally-funded projects related to the WFU OAIC research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. A high priority for the CRC will be to support clinical trials translating basic research discoveries into human population studies; clinical research targeting sarcopenia and adiposity-related decline in physical function and disability in older adults; and trials of novel interventions related to these risk factors. The CRC will also assist the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the Research Career Development Core (RCDC) in identifying promising new investigators and programs positioned to help to address the mechanisms and prevention of physical disability. The CRC will provide 'turn-key' resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment 3) a standardized physical function assessment battery; 4) procurement (with the Integrative Biology Core) of muscle and adipose tissue and blood samples; 5) maintenance (in concert with the Biostatistics Core) of a uniform outcomes database; 6) assisting junior investigators with IRB and other regulatory filings (in concert with the PESC and RCDC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grant awards, and development of new investigators.