Center for Adaptive Neurotechnologies

描述（由申请人提供）：Wadsworth的科学家和工程师正在建立一个独特的技术基础设施，支持与中枢神经系统（CNS）的实时交互。他们正在利用它产生重要的新的科学见解和新的临床方法，并开始将这些成果传播给其他人。拟建的适应性神经技术中心将继续并扩大这一努力，加强对临床转化的关注，并加速新技术的传播。它有五个具体目标。目的1将开发和验证新的操作性条件反射方案，该方案可以修改特定的脊髓和脊髓皮质中枢神经系统通路，以诱导和指导中枢神经系统的有益（即康复）可塑性。这些协议还将被纳入一个紧凑而强大的单元，以使这种新的治疗方法能够在运动障碍患者中广泛使用。目标2将开发和验证基于脑电图（EEG）的脑机接口（BCI）系统，该系统可以改善重要的中枢神经系统功能，例如严重神经肌肉残疾（例如中风）患者的运动控制和成瘾障碍患者的情绪调节（从而减少渴望和药物滥用）。目标3将开发和验证使用皮层表面皮质电图（ECoG）信号的方法，以超越目前可能的时间和空间分辨率来定位和表征大脑过程。这项工作将为ECoG信号的建模、共配准、表示和减少开发新的算法；并将它们整合到实时软件中，用于检测、绘制和与潜在的特定功能和功能障碍的大脑过程互动。目标4将创建一个新的跨学科培训课程，提供适应性神经技术的理论基础和将其应用于重要的科学和临床应用的实践经验。该课程将纳入培训课程和讲习班。目标5将开发和支持自适应神经技术的传播渠道，包括：高度互动的中心网站；《科学》杂志的评论文章，

DESCRIPTION (provided by applicant): Wadsworth scientists and engineers are building a unique technological infrastructure that supports real time interactions with the central nervous system (CNS). They are using it to produce important new scientific insights and novel clinical methods, and they are beginning to disseminate these achievements to others. The proposed Center for Adaptive Neurotechnologies will continue and expand this effort, strengthen its focus on clinical translation, and accelerate dissemination of the new technologies. It has five specific aims. Aim 1 will develop and validate new operant conditioning protocols that can modify specific spinal and corticospinal CNS pathways to induce and guide beneficial (i.e., rehabilitative) plasticity in the CNS. These protocols will also be incorporated into a compact and robust unit to enable widespread use of this new therapeutic method in people with motor disabilities. Aim 2 will develop and validate electroencephalography(EEG)-based brain-computer interface (BCI) systems that can improve important CNS functions, such as motor control in people with severe neuromuscular disabilities (e.g., stroke) and emotion regulation in people with addiction disorders (thereby reducing craving and substance abuse). Aim 3 will develop and validate methods that use electrocorticographic (ECoG) signals from the cortical surface to localize and characterize brain processes with temporal and spatial resolution beyond that now possible. This work will develop novel algorithms for modeling, co-registration, representation, and reduction of ECoG signals; and will incorporate them into real-time software for detecting, mapping, and interacting with the brain processes underlying specific functions and dysfunctions. Aim 4 will create a novel interdisciplinary training curriculum that provides a theoretical foundation in adaptive neurotechnologies and practical experience in applying them to important scientific and clinical applications. This curriculum will be incorporated into training courses and workshops. Aim 5 will develop and support dissemination channels for adaptive neurotechnologies, including: the highly interactive Center website; review articles in scientific, engineering, and clinical journals; and presentations and workshops at scientific and clinical meetings.