Genomic Resource Grant for PhenX Toolkit (U41)

“PhenX工具包-基因组研究的标准措施”将维护和扩展PhenX工具包 以满足科学界不断变化的需求。该工具包目前包括21个研究领域， 和7个与药物滥用和成瘾有关的措施集。该工具包拥有广泛的用户基础， PhenX措施正在进行的研究中也包括在内。拟议工作的目标是解决 四个新的研究领域，对21个研究领域进行滚动审查和更新，以整合 工具包协议的中文和西班牙语翻译，以扩展到社交媒体，以加强我们的合作 利用基因型和表型数据库(DBGaP)，并使PhenX测量在所有人中都可见 已完成的研究保存在数据库数据库中。我们还将促进与相关措施努力的合作(例如， 患者报告结果测量信息系统[PROMIS]和美国国立卫生研究院 卫生[NIH]工具箱)，强调了这些方法的互补性并确定了协同作用。 总而言之，这些努力将吸引更多的用户使用工具包，并提高对工具包作为 为科学界提供了重要的、有用的资源。广泛采用PhenX措施将促进 交叉研究分析，从而增加个别研究的科学影响。在持续的支持下，PhenX 将促进和推进整个生物医学研究界的合作研究。

"The PhenX Toolkit-Standard Measures for Genomics Research" will maintain and expand the PhenX Toolkit to meet the evolving needs of the scientific community. The Toolkit currently includes 21 research domains, and 7 collections of measures related to Substance Abuse and Addiction. The Toolkit has a broad user base, and PhenX measures are being included in ongoing studies. The goals of the proposed work are to address four new research domains, to implement a rolling review and update of the 21 research domains, to integrate Chinese and Spanish translations of Toolkit protocols, to expand into social media, to build on our collaboration with the database of Genotypes and Phenotypes (dbGaP), and to make PhenX measures visible in all completed studies deposited in dbGaP. We will also foster collaborations with related measures efforts (e.g., the Patient Reported Outcomes Measurement Information System [PROMIS] and the National Institutes of Health [NIH] Toolbox), highlighting the complementary nature of these approaches and identifying synergies. Taken together, these efforts will attract additional users to the Toolkit and raise awareness of the Toolkit as an important, helpful resource for the scientific community. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies. With continued support, PhenX will promote and advance collaborative research across the biomedical research community.