PATHOLOGY

为了确定实验性干预对衰老的影响，研究人员必须具备 了解干预如何改变随年龄增长而发生的病理损害。年龄相关病理学 随着年龄的增长呈指数增长，这在很大程度上是与年龄相关的发病率以及 死亡率。病理信息也为研究人员提供了对潜在的 干预的生物学/分子机制(S)。此外，老年性痴呆的病理评估 包括在生物衰老过程基础研究中的动物是必要的，以帮助研究人员 确定所测量的生理/生化参数的变化是否与或 与潜在的病理条件无关。因此，必须获得准确和彻底的 衰老动物的病理评估。病理核心将提供三个方面的调查人员 对随年龄增长发生在殖民地的病变进行详细的临终病理分析的项目 组织特异性(肝脏、骨骼肌和白色脂肪组织[Wat])GHRKO小鼠。病理学的核心 还将为四个项目的调查人员提供具体的横断面病理分析 来自Ames Dwarf、GHRKO和组织特异性GHRKO小鼠的组织。 病理学核心的具体目标如下： 目的1：对转基因小鼠及其野生小鼠进行全面的病理学分析。 在老化的群体中自发死亡或濒临死亡的类型窝种。 目的2：对遗传来源的组织进行横断面组织病理学分析 被操控的小鼠和它们的后代。这些数据将使调查人员能够评估 遗传操作对特定组织在特定年龄的组织学变化。 相关性(请参阅说明)：

To determine the impact of an experimental intervention on aging, it is essential that an investigator have knowledge of how the intervention alters the pathological lesions that occur with age. Age-related pathology increases exponentially with advancing age and is largely responsible for age-related morbidity as well as mortality. Pathological information also provides investigators with insight into the potential biological/molecular mechanism(s) of the intervention. Furthermore, the pathological assessment of old animals that are included in basic studies of biological aging processes is necessary to help investigators determine whether the changes in physiological/biochemical parameters measured are associated with or are independent of underlying pathological conditions. Thus it is essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core will provide investigators in the three Projects with detailed end-of-life pathological analyses of the lesions that occur with age in colonies of tissue-specific (liver, skeletal muscle and white adipose tissue [WAT]) GHRKO mice . The Pathology Core will also provide investigators in the four Projects with cross-sectional pathological analyses of the specific tissues obtained from Ames dwarf, GHRKO and tissue-specific GHRKO mice. The Specific Aims of the Pathology Core are as follows: Aim 1: To conduct comprehensive pathological analyses of the genetically manipulated mice and their wild- type littermates that die spontaneously or are in the moribund category in the aging colonies. Aim 2: To conduct cross-sectional histopathological analyses of tissues obtained from genetically manipulated mice and their littermates. These data will allow investigators to evaluate the effect of the genetic manipulations on the histological changes in specific tissues at specific age. RELEVANCE (See instructions):