Cerebrovascular Fellowship Training Program

项目概述/摘要我们的培训计划的总体目标是培训和指导来自神经病学和急诊医学学科的内科临床研究人员，他们将成为中风和脑血管疾病病因和治疗调查的合作领导者和临床试验研究者，或在神经危重症临床研究领域的临床研究人员。我们为期两年的培训计划包括在美国国立卫生研究院资助的一系列广泛的临床研究和试验中，在脑血管疾病和中风以及神经危重症护理环境中的其他急性神经系统疾病领域进行T-2重点转化研究的广泛实践经验。我们的项目包括密切指导，在项目的第一年选择具体的研究项目；明确生物统计学、流行病学、临床试验、伦理学、信息学等课程，并根据学员的研究重点定制课程；讲授流行病学、病理生理学、脑卒中/脑血管疾病以及其他急性神经系统疾病的治疗和预后；与基础科学家及其正在进行的研究项目进行良好的互动，指导学员实现独立的学术生涯；以及在评估和治疗急性中风患者或需要神经危重症护理的患者方面的独特培训。这种创新的、多学科的培训模式已经被NIH路线图所倡导，最近也被NIH资助的临床和转化科学与培训中心（CCTST）所倡导。我们的培训计划由广泛的合作者和导师网络组成，这导致了我们毕业生的学术生产力。培训利用在急性中风治疗和临床试验方法/管理、基因组学、出血性中风、中风和血管生理学的动物模型和体外模型、创伤性脑损伤、神经危重症护理方法、神经流行病学、生物统计学、神经介入治疗（血管内和外科）、神经影像学、神经恢复、神经超声学、神经技术发展、结果研究、中风预防、研究的伦理设计、HIPAA遵从性和数据库管理。我们的学员是两个独立的国家科学研究院资助的中心网络（SPOTRIAS和NETT）的一部分，其中研究培训是主要目标。潜在的受训者必须完成神经病学或急诊医学的住院医师培训，并且必须证明对脑血管疾病和/或神经危重症护理的学术生涯的承诺；强调少数民族的招聘。

DESCRIPTION (provided by applicant): Project Summary / Abstract The overall goal of our training program is to train and mentor physician clinical researchers from the disciplines of neurology and emergency medicine who will become collaborative leaders and clinical trial investigators in the investigation of the causes and treatment of stroke and cerebrovascular disease or clinical researchers in the significantly underserved clinical research arena of neurocritical care. Our two-year training program includes extensive hands- on experience in clinical research and trials within a broad array of NIH-funded, T-2 focused, translational research in the area of cerebrovascular disease and stroke as well as other acute neurologic diseases in a neurocritical care setting. Our program includes close mentoring with selection of specific research projects within the first year of the program; well-defined course work in biostatistics, epidemiology, clinical trials, ethics, informatics, and customized course work based upon the trainees' research focus; lectures in the epidemiology, pathophysiology, treatment and outcome of stroke/cerebrovascular disease as well as other acute neurologic diseases treated in the neurocritical care setting; excellent interactions with basic scientists and their ongoing research projects, mentoring trainees in achieving an independent academic career; and unique training in the evaluation and treatment of patients with acute stroke or who require neurocritical care. This innovative and multi-disciplinary training model has been advocated by the NIH roadmap and more recently by the NIH-funded Centers for Clinical and Translational Science and Training (CCTST). Our training program is comprised of an extensive network of collaborators and mentors that has resulted in academic productivity among our graduates. Training draws on faculty with expertise in acute stroke therapy and clinical trial methodology/management, genomics, hemorrhagic stroke, animal models and in-vitro models of stroke and vascular physiology, traumatic brain injury, methods of neurocritical care, neuro- epidemiology, biostatistics, neuro-interventional therapy (endovascular and surgical), neuroimaging, neurorecovery, neurosonology, neurotechnology development, outcome research, stroke prevention, ethical design of research, HIPAA compliance, and data-base management. Our trainees are part of two separate NINDS-funded networks of centers (SPOTRIAS and NETT) in which research training is a major goal. Potential trainees must have completed a residency in neurology or emergency medicine and must demonstrate a commitment to an academic career in cerebrovascular disease and/or neurocritical care; minority recruitment is emphasized.