Development and Maintenance of Software for MR Spectroscopic Imaging

描述（由申请人提供）：MIDAS（代谢成像数据分析系统）软件包为磁共振光谱成像（MRSI）数据的处理、显示和分析提供了全面而独特的功能，并与结构和其他参数MRI模式的信息紧密集成。该系统支持体积回波-平面光谱成像（EPSI）采集，可提供包括皮质表面区域在内的大范围大脑的高分辨率图像，已在三家主要制造商的MR仪器上实现。EPSI和MIDAS软件已分发到世界各地的多个站点。在四个具体目标下，该项目将维护和开发这些软件包的新功能。Aim 1将增加新的光谱和图像处理功能，其中将包括脑温度、代谢物T2和研究之间参数变化的体积测绘能力。目标2将通过在公共编程环境下重构历史上不同的代码片段来改进性能、软件组织和可维护性。Aim 3将通过未来的系统升级支持EPSI采集，并为数据采集方法增加新的功能。目标4将继续开发用户文档、教育材料和项目网站，并提供从以前的项目中获得的数据。通过这些目标，该项目将为高度创新的功能套件提供持续的支持和发展，以促进临床和基础生物医学成像研究使用MRI和MRSI。

DESCRIPTION (provided by applicant): The MIDAS (Metabolic Imaging Data Analysis System) software package provides comprehensive and unique functionality for processing, display, and analysis of MR Spectroscopic imaging (MRSI) data, and includes close integration with information available from structural and other parametric MRI modalities. This system supports a volumetric echo- planar spectroscopic imaging (EPSI) acquisition that provides high-resolution images of a wide extent of the brain, including cortical surface regions, which has been implemented on MR instruments from three major manufacturers. The EPSI and MIDAS software have been distributed to multiple sites worldwide. Under four specific aims this project will maintain and develop new functionality for these packages. Aim 1 will add new spectroscopy and image processing functions, which will include capabilities for volumetric mapping of brain temperature, metabolite T2, and parametric changes between studies. Aim 2 will improve performance, software organization, and maintainability by refactoring historically diverse pieces of code under a common programming environment. Aim 3 will support the EPSI acquisition through future system upgrades and add new capabilities to the data acquisition methods. Aim 4 will continue development of user documentation, educational materials, and the project web site, and make available data acquired under previous projects. Through these aims this project will provide continued support and development for a highly innovative suite of functions that facilitate clinical and basic biomedical imaging research studies using MRI and MRSI.