Oklahoma Center for Respiratory and Infectious Diseases

描述（由申请人提供）：这个COBRE申请的总体目标是通过建立多机构研究中心，俄克拉何马州呼吸和传染病中心，在呼吸道传染病领域实现指导的卓越研究。俄克拉何马州立大学（OSU）兽医健康科学中心（CVHS）将牵头开展该项目，俄勒冈州立大学的四所学院、俄克拉何马大学健康科学中心的两所学院和俄克拉何马医学研究基金会将参与该项目。俄勒冈州立大学兽医学院是美国最小的兽医学院之一。然而，CVHS领导人不断承诺改善研究基础设施和开发研究项目。目前COBRE应用的中心科学主题是呼吸系统传染病，重点是呼吸道合胞病毒（RSV）、流感病毒和细菌感染。四个跨学科项目涵盖疾病发病机制、治疗学、分子机制和生物工程。目的：我将制定一个指导计划，指导有前途的初级研究人员（PJIs）成为独立的美国国立卫生研究院资助的研究人员，从而在呼吸道传染病领域建立一个多学科研究人员的临界质量。这一目标将通过以下方式实现：1)指导4名有前途的pji， 2)为中心招募6名新的终身教职员工，以及3)管理一个试点项目资助计划，以吸引更多的pji和其他研究人员进入主题研究领域。目标2将通过建立科研核心（动物模型、免疫病理学和分子生物学）来建立研究基础设施，以支持PJIs和中心研究人员的研究工作。目标3将通过俄克拉何马州呼吸和传染病中心建立和促进科学互动，促进俄克拉何马州的机构间合作。目前COBRE目标的完成将对俄克拉荷马州呼吸道传染病的研究项目产生重大影响。

DESCRIPTION (provided by applicant): The overall objective of this COBRE application Is to achieve mentored research excellence in the field of respiratory infectious diseases by establishing the multi-institutional research center, Oklahoma Center for Respiratory and Infectious Diseases. The Oklahoma State University (OSU) Center for Veterinary Health Sciences (CVHS) will take the lead for this program with a participation of four colleges from OSU, two colleges from the University of Oklahoma Health Sciences Center, and the Oklahoma Medical Research Foundation. OSU CVHS is one of the smallest veterinary colleges in the US. However, CVHS leaders have continuously made commitments to improve research infrastructure and to develop research programs. The central scientific theme for the current COBRE application is infectious diseases of the respiratory system with a focus on respiratory syncytial virus (RSV), influenza virus, and bacterial infections. The four interdisciplinary projecs cover disease pathogenesis, therapeutics, molecular mechanisms, and bioengineering. Aim I will develop a mentoring program to guide promising junior investigators (PJIs) in becoming independent NIH-funded investigators and thus create a critical mass of multi-disciplinary investigators in respiratory infectious diseases. This aim will be accomplished by 1) mentoring four promising PJIs, 2) recruiting six new tenure-track faculty members dedicated to the Center, and 3) administering a Pilot Project Grant program to attract additional PJIs and other investigators into the thematic area of research. Aim 2 will build up research infrastructure to support research efforts of PJIs and the Center investigators by establishing scientific research cores (Animal Model, Immunopathology, and Molecular Biology). Aim 3 will foster inter-institutional collaborations in Oklahoma by establishing and promoting scientific interactions through the Oklahoma Center for Respiratory and Infectious Diseases. The completion of the goals of the present COBRE will have a major impact on research programs on respiratory infectious diseases in the State of Oklahoma.