Harvard Trauma Inflammation Training Program

申请者描述(由申请人提供)：本申请旨在为3名医学博士和3名博士生提供创伤、烧伤和围手术期损伤方面的T32培训计划的资金，他们将在贝丝以色列女执事医学中心(BIDMC)和哈佛医学院(HMS)其他附属教学医院的以翻译为导向的内科科学家和基础研究人员的实验室进行创伤研究。哈佛大学朗伍德医学区拥有一系列令人印象深刻的临床和研究设施，这将是 提出的T32计划，这将是该领域的第一个此类计划。该计划将由创伤、休克和炎症研究领域经验丰富的多学科领导团队指导。这项拟议计划的研究重点集中在创伤引发炎症过程和器官衰竭的早期事件上，目的是开发新的治疗方法来预防炎症到器官功能障碍。我们提出了一项培训计划，将教授免疫学、生物化学、分子生物学和创伤的先天免疫反应方面的最新知识。一个长期目标是培养创伤研究领域的未来领导者，他们拥有在该领域取得切实进展所需的必要的跨学科团队合作技能。我们建议通过将医学博士和博士实习生配对来教授这些技能。这些人将在紧密的跨学科团队中工作。医学博士实习生将帮助他们的博士伙伴了解创伤护理中的实际临床问题；博士实习生将教他们的MD伙伴如何用尖端科学方法解决这些问题。双方将学习如何有效地相互沟通，以及如何在互惠互利的跨学科研究团队中解决实际的临床问题。对这种创新训练方法的需求是由以下基本原理驱动的：�尽管几十年来进行了大量的研究工作，但炎症并发症、免疫功能障碍和器官衰竭仍然是创伤后发病率和死亡率的主要原因。�在临床创伤护理方面的显著进步，以及我们对推动创伤后炎症的免疫学、细胞和分子过程的理解的巨大进步，并未转化为临床结果的相应改善。�造成这一缺陷的一个核心原因是临床和基础研究人员之间的信息流不足。因此，需要一种新的科学培训模式来培养创伤研究领域的领导者，他们可以通过发展强大的跨学科团队合作技能来弥合这一差距，帮助他们在创伤后推进该领域并改善临床结果。项目主任本身已经建立了这种跨学科的伙伴关系，因此将成为榜样。他们聚集了一群令人印象深刻的备受尊敬和积极进取的基础研究人员和临床教师，他们将在他们的实验室指导受训人员。我们建议在创伤相关研究实验室招收3名医学博士和3名博士实习生，每人至少2年。预计MDS将完成2-3年的普通外科临床培训，并在危重护理、创伤外科或相关专业追求学术生涯。博士候选人将根据在创伤或炎症研究、免疫学或相关研究领域的兴趣或经验来选择。为了促进跨学科的团队合作技能，学员将组成3个团队，每个团队由博士和博士学员组成。每个团队合作伙伴将在创伤研究的相关主题内进行单独的项目工作。通过共同出席会议、研讨会和讲座，鼓励他们建立密切的联系。MD实习生将指导他们的博士伙伴进行临床查房，以深入了解危重创伤患者护理中的实际临床问题。博士生将依次提供 他们与医学博士合作，在设计实验和研究战略以及接触新技术方面提供建议和帮助。该培训计划将帮助学员认识到跨学科团队合作的价值，以及密切合作的临床和基础科学家之间活跃的信息流的好处。这种培训方式和哈佛朗伍德地区一流的研究基础设施将帮助我们实现我们的总体目标，即培养一批能够推动创伤研究领域并改善临床创伤护理的新型熟练研究人员。

DESCRIPTION (provided by applicant): This application seeks funding for a T32 Training Program in Trauma, Burn, and Peri-operative Injury for 3 MD and 3 PhD trainees who will conduct trauma research in the laboratories of translationally oriented physician scientists and basic researchers at the Beth Israel Deaconess Medical Center (BIDMC) and other affiliated teaching hospitals of Harvard Medical School (HMS). The Harvard Longwood Medical Area holds an impressive array of clinical and research facilities that will be an ideal setting for the proposed T32 program, which will be the first of its kind in this area. The program will be directed by a multidisciplinary team of experienced leaders in the field of trauma, shock, and inflammation research. The research focus of this proposed program is centered on the early events leading to the inflammatory process and organ failure triggered by trauma with the aim of developing novel treatments to prevent inflammation to organ dysfunction. We propose a training program that will teach state-of-the-art knowledge in immunology, biochemistry, molecular biology, and the innate immune response to trauma. A long-term goal is to develop future leaders in the field of trauma research who have the necessary interdisciplinary teamwork skills that are required for to make tangible progress in the field. We propose to teach these skills by pairing MD and PhD trainees. These pairs will work in close interdisciplinary teams. MD trainees will help their PhD partners understand actual clinical problems in trauma care; PhD trainees will teach their MD partners how to address these problems with leading-edge science approaches. Both partners will lean how to communicate effectively with one another and how to solve real clinical problems in mutually beneficial interdisciplinary research teams. The need for this innovative training approach is driven by the following rationale: � despite intense research efforts over several decades, inflammatory complications, immune dysfunction, and organ failure have remained major causes of post-traumatic morbidity and mortality. � Remarkable progress in clinical trauma care and vast improvements in our understanding of the immunological, cellular, and molecular processes that drive post-traumatic inflammation have not translated into corresponding improvements in clinical outcome. � A core reason for this deficit is inadequate information flow among clinical and basic researchers. Thus, a new paradigm of science training is needed to raise leaders in trauma research who can bridge this gap by developing strong interdisciplinary teamwork skills that help them advance the field and improve clinical outcome after trauma. The program directors themselves have established such interdisciplinary partnerships and will therefore serve as role models. They have gathered an impressive group of highly respected and motivated basic researcher and clinical faculty who will mentor trainees in their laboratories. We propose a program that will host 3 MD and 3 PhD trainees for a minimum of 2 years each in trauma related research laboratories. MDs are expected to have completed 2-3 years of clinical training in general surgery and to pursue an academic career in critical care, trauma surgery, or related specialties. PhD candidates will be selected based on documented interest or experience in trauma or inflammation research, immunology, or in related fields of study. In order to promote interdisciplinary team working skills, trainees will form 3 teams consisting of a PhD and MD trainee each. Each team partner will work on individual projects within related topics in trauma research. They will be encouraged to form close ties through joint attendance of conferences, seminars, and lectures. MD trainees will guide their PhD partner on clinical rounds to provide an in-depth understanding of actual clinical problems in the care for critically ill trauma patients. PhD trainees in turn will provide their MD partners with advice and assistance in the design of experiments and research strategies as well as exposure to new technologies. This training program will help trainees recognize the value of interdisciplinary team work and the benefit of vigorous information flow between closely collaborating clinical and basic scientists. This training approach and the excellent research infrastructure in the Harvard Longwood Area will help us achieve our overall goals, namely to develop a new breed of skilled researcher who can advance the field of trauma research and improve clinical trauma care.