Role of brown adipose tissue (BAT) in energy balance

二零一五财政年度的进展包括以下各项： 我们研究了CL 316243（一种β 3-肾上腺素能激动剂）在热中性（30 ℃）和典型动物园温度（22 ℃）下对小鼠的慢性BAT刺激。 与22 ℃相比，30 ℃下溶剂处理的对照小鼠的食物摄入量、代谢率和棕色脂肪活性降低，并且由于30 ℃下对适应性产热的需求最小而导致肥胖增加。在两种温度下，CL 316243处理增加了棕色脂肪活化和能量消耗，并改善了葡萄糖耐量。在30 ℃时，CL 316243增加的能量消耗与食物摄入量的变化不成比例，从而减少肥胖，而在22 ℃时，这些变化相匹配，产生不变的肥胖。 我们得出结论，β 3-肾上腺素能受体激动剂治疗可以在没有肥胖改变的情况下产生有益的代谢作用。

Progress in FY2015 includes the following: We studied chronic BAT stimulation with CL316243, a beta3-adrenergic agonist in mice at thermoneutrality (30C) and at a typical vivarium temperature (22C). Vehicle-treated control mice at 30C, compared to 22C, had reduced food intake, metabolic rate, and brown adipose activity, as well as increased adiposity due to the minimal need for adaptive thermogenesis at 30C. At both temperatures, CL316243 treatment increased brown adipose activation and energy expenditure and improved glucose tolerance. At 30C, CL316243 increased energy expenditure disproportionately to changes in food intake, thus reducing adiposity, while at 22C these changes were matched, yielding unchanged adiposity. We conclude that beta3-adrenergic agonist treatment can have beneficial metabolic effects in the absence of adiposity changes.