Administrative Core

摘要 两个SUNY医学院（SUNY斯托尼布鲁克和SUNY Downstate）为代表性不足的少数族裔提供服务 有癌症健康差异的社区正在与NCI指定的癌症中心合作， Spring Harbor Laboratory（CSHL）评估GI癌症（结直肠癌和结肠癌）的生物学和遗传学差异。 胰腺），这可能与在种族和民族中观察到的癌症发病率和结局的差异有关。 少数民族（URM）。对于癌症研究计划，我们的目标是增加代表性， 少数民族在生物标本和相关的高维“omic”数据集的收集中代表性不足 这些生物标本的基因在这项计划拨款中，我们计划开发一个纽约州立大学Downstate GI生物库， 与纽约州立大学斯托尼布鲁克GI生物银行平行运作，使用标准操作程序。我们 计划开发一个综合生物医学信息学平台，将生物标本与 纵向临床数据和从这些标本生成的数据。规划的第一步 过程的目的是就包括哪些数据元素以及受控词汇表达成共识。到 增加种族和少数民族人口的社区参与性研究，我们计划利用 纽约州立大学下州布鲁克林健康差异中心的资源和专业知识（由摩罗萨利夫博士领导） 在服务水平低下的社区开展社区教育和外展计划， 种族和少数民族。生物标本的收集将由两个试点研究项目推动，P1 和P2。在P1中，我们建议比较URM结肠癌和非URM结肠癌的基因组和表观遗传学特征， 结肠癌在P2中，我们建议测试采用创新的3-D方法来生长的可行性 胰腺类器官（微型胰腺）来自祖细胞（在Tuveson博士的实验室开发， CSHL）从两个SUNY医疗中心收集的人类胰腺癌细针芯活检中获得 校园。我们计划将URM胰腺类器官的基因组和表观基因组图谱与 非URM类器官。对于培训和教育计划，我们致力于改善 代表性不足的少数群体参与生物医学研究和提高健康意识 癌症研究人员之间的差异。在这项规划中，纽约州立大学的两个医学院 将与CSHL合作，创建一个综合的博士证书课程，生物医学科学学者， 癌症健康差异。该计划旨在让博士生从事转化医学， 特别是在癌症健康差异方面，通过促进这些学生对演讲的理解， 与论文研究领域相关的疾病进展和治疗。这条赛道需要增加 一个临床共同导师通常的学生基础科学顾问团队谁将帮助指导学生的 生物医学/临床研究，并沉浸在临床经验，词汇和整体的学生 临床研究文化。

ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratory (CSHL) to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of biospecimens and linked high dimensional ‘omic datasets generated from these biospecimens. In this planning grant we plan to develop a SUNY Downstate GI Biobank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the biospecimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of biospecimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson’s laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program, Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.