Training and Education Program

摘要 两所纽约州立大学医学院(纽约州立大学石溪分校和纽约州立大学下州分校)为少数族裔提供服务 有癌症健康差距的社区正在与NCI指定的寒冷癌症中心合作 春港实验室评估胃肠道癌症的生物学和遗传差异(结直肠癌和 胰腺)，这可能与在种族和少数民族中观察到的癌症发病率和预后的差异有关 (URM)。对于癌症研究计划，我们的目标是增加代表性不足的少数族裔的代表性 在生物样本和从这些生物样本和链接的高维基因组数据集的集合中 生物群落。在这项规划拨款中，我们计划开发一家纽约州立大学下州GI生物库，该生物库并行运行 使用标准操作程序到纽约州立大学石溪GI生物库。我们正在规划开发项目 一个整合的生物医学信息学平台，将把生物标本与纵向临床数据联系起来，并 从这些标本中产生的数据。规划程序的第一步是制定一个 就包括哪些数据元素和开发受控词汇表达成共识。为了增加社区 在种族和少数族裔人口中进行参与性研究，我们计划利用这些资源和 纽约州立大学布鲁克林健康差异中心(由Moro Salifu博士领导)在制定 在服务不足、种族和性别比例较高的社区开展社区教育和外展计划 少数民族。收集生物寄生虫将由两个试点研究项目--P1和P2--推动。在P1中， 我们建议比较URM结肠癌和非URM结肠癌的基因组和表观遗传学特征。 在P2中，我们建议测试采用一种创新的3D方法来培养胰腺类器官的可行性 (微型胰腺)来自细针的祖细胞(在CSHL的Tuveson博士的实验室中培育) 在纽约州立大学两个医学院收集的人类胰腺癌的核心活检组织。我们计划比较一下 URM胰腺器官与非URM器官的基因组和表观基因组图谱。对于 培训和教育方案，我们致力于改善代表不足的少数群体的参与 在生物医学研究和提高现有癌症研究人员对健康差距的认识方面。 在这项计划拨款中，两个纽约州立大学医学院将与CSHL合作，创建一个综合博士 癌症健康差异生物医学学者证书计划。这一计划旨在 让博士生参与转化医学，特别是在癌症健康差异方面，通过在这些方面进行推广 学生了解与他们所在领域相关的疾病的表现、进展和治疗 论文研究。该课程要求在通常的学生基础科学顾问的基础上增加一名临床辅导员 帮助指导学生的生物医学/临床研究并让学生沉浸在临床中的团队 临床研究的经验、词汇和整体文化。

ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of biospecimens and linked high dimensional ‘omic datasets generated from these biospecimens. In this planning grant we plan to develop a SUNY Downstate GI Biobank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the biospecimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations,we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of biospecimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson’s laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.