Wisconsin Alzheimer's Disease Research Center

描述（申请人提供）：威斯康星州阿尔茨海默病研究中心拟议更新的总体目标（威斯康星州ADRC）是通过建立一个刺激，通过提供宝贵的临床和死后数据以及死前生物标本，为合作研究提供跨学科的环境。由NIA在2009年资助，威斯康星州ADRC将支持七个整合良好的核心，包括一个新的神经影像核心，这将支持全方位的及时，创新的研究，包括研究，将：1）靶向AD临床前阶段的先行生物标志物，2）研究AD的神经生物学，3）鉴定新的血管和遗传风险因素并将其与疾病病理学和临床表型联系起来，4）将当代生物化学和分子技术结合到临床病理学队列研究中，包括基因组学、表观基因组学、蛋白质组学和下一代基因测序; 5）参与并促进其他联邦、州和地方机构支持的老龄化和痴呆症研究计划和研究的任务。 威斯康星州ADRC的总体目标将通过其七个核心的协调活动来实现。行政核心将为整个ADRC提供科学领导。临床中心将进行标准化评价，并收集所有研究参与者的UDS和其他数据。它将与外展、招聘和教育（ORE）以及少数民族招聘卫星方案（MRSP）核心密切合作，以提高代表性不足的少数民族在ADRC的入学率。数据管理和统计核心将继续满足各核心的所有数据管理、信息学和统计需求。它将继续支持所有基于个人电脑和网络的服务和进程。神经病理学核心将继续处理，评估，储存和分发生前生物标本和死后组织，以支持AD的新研究。ORE核心将提供有关AD的广泛教育和推广计划，以及威斯康星州ADRC招募研究志愿者的使命，特别是那些有色人种进入临床核心和其他NIA资助的计划，如ADCS，ADNI，NCRAD和GWAS研究。MRSP核心将与ORE和临床核心密切合作，以加强少数民族参与者的招募和保留。新的神经成像核心将汇集华盛顿大学在神经成像方面的所有资源和专业知识，以制定一个协调良好的计划，这将显着加强AD和相关疾病神经成像的跨学科合作研究。 威斯康星州ADRC的成功更新将使该中心能够继续进行针对AD临床前阶段的先行生物标志物的新研究。这些研究的结果将导致早期诊断和发现AD的新治疗和预防策略，这将显着减少该疾病的人类痛苦和社会经济负担。

DESCRIPTION (provided by applicant): The overall goal of the proposed renewal of the Wisconsin Alzheimer's Disease Research Center (Wisconsin ADRC) is to support cutting-edge and innovative research on the etiology, pathogenesis, diagnosis and treatment of Alzheimer's disease (AD) and related illnesses by establishing a stimulating, interdisciplinary environment for collaborative research and by providing invaluable clinical and postmortem data and ante- mortem biospecimens. Funded by NIA in 2009, the Wisconsin ADRC will support seven well-integrated Cores, including a new Neuroimaging Core, that will support a full-spectrum of timely, innovative research including studies that will: 1) target antecedent biomarkers of preclinical stages of AD, 2) investigate the neurobiology of AD, 3) identify novel vascular and genetic risk factors and linking them to the disease pathology and clinical phenotype, 4) incorporate contemporary biochemical and molecular techniques into clinical-pathologic cohort studies, including genomics, epigenomics, proteomics and next generation genetic sequencing and 5) participate and facilitate the missions of other federal, state and local agency supported aging and dementia research programs and studies. The overall goals of the Wisconsin ADRC will be accomplished through coordinated activities of its seven Cores. The Administrative Core will provide scientific leadership to the ADRC as a whole. The Clinical Core will perform standardized evaluations and collect UDS and additional data on all research participants. It will work closely with the Outreach, Recruitment and Education (ORE) and the Minority Recruitment Satellite Program (MRSP) Cores to enhance enrollment of underrepresented minorities into the ADRC. The Data Management and Statistical Core will continue to meet all the data management, informatics and statistical needs of the cores. It will continue to support all the PC- and web-based services and processes. The Neuropathology Core will continue to process, evaluate, store and distribute antemortem biospecimens and postmortem tissue to support novel research in AD. The ORE Core will provide a wide-range of educational and outreach programs about AD and the missions of Wisconsin ADRC to recruit research volunteers, especially those of color into the Clinical Core and other NIA-funded initiatives, such as ADCS, ADNI, NCRAD and GWAS studies. The MRSP Core will work closely with the ORE and Clinical Cores to enhance recruitment and retention of minority participants into the ADRC. The new Neuroimaging Core will bring together all the resources and expertise of the UW in neuroimaging to develop a well-coordinated program that will significantly enhance collaborative interdisciplinary research in neuroimaging of AD and related diseases. Successful renewal of the Wisconsin ADRC will allow the Center to continue to conduct novel studies targeting antecedent biomarkers of preclinical stages of AD. Findings from these studies will result in an early diagnosis and discovery of new treatment and prevention strategies for AD that will significantly reduce the human suffering and socio-economic devastations of the disease.