Stanford OHNS Core Center

描述（由申请人提供）：斯坦福大学OHNS核心中心分为两个核心设施：核心I -成像核心和核心II -内耳生理学核心。这两个核心有助于促进对内耳功能，发育和治疗策略的基本机制的跨学科合作研究。核心中心的用户群包括十几名主要研究人员，他们从事广泛的分子、生物物理、发育、整体动物以及基于工程的项目，所有这些项目都与NIDCD的使命相关。两个核心都在追求三个目标，一个总体战略和理念，核心中心作为知识和技术的中心（目标1），目标是建立一个知情的用户群，学生，博士后研究员和教师分享成功，但最重要的是问题和解决方案。这反过来又刺激了合作研究（目标2），因为它教会了批判性思维和团队解决问题。最后，核心中心提供最先进的技术（目标3），可用于解决内耳相关问题和研究。这些资源对于一个实验室来说是遥不可及的，因为维护和适当利用这些设备的成本在经济上是无法承受的。

DESCRIPTION (provided by applicant): The Stanford OHNS Core Center is organized into two Core facilities: Core I - Imaging Core and Core II - Inner Ear Physiology Core. Both cores serve to facilitate interdisciplinary collaborative research on the basic mechanisms of inner ear function, development, and therapeutic strategies. The Core Center user base comprises more than a dozen Principal Investigators working on a broad range of molecular, biophysical, developmental, whole animal, as well as engineering based projects all on topics that are of relevance to the mission of the NIDCD. Three goals are being pursued in both cores with an overarching strategy and philosophy where the Core Center serves as a hub for knowledge and technology (Aim 1) with the goal of generating an informed user base where students, postdoctoral fellows, and faculty share successes but most importantly also problems and solutions. This, in turn, stimulates collaborative research (Aim 2) because it teaches critical thinking and solving problems as a team. Finally, the Core Center makes available access to state-of-the-art technology (Aim 3) uniquely applicable to solving inner ear-related questions and research. These resources would be out of reach for a single laboratory simply because the costs to maintain and appropriately utilize the equipment would be economically unbearable.