Pediatric Neurointensive Care and Resuscitation Research

描述（由申请人提供）：儿童急性危及生命的损伤，如创伤性脑损伤（TBI）和心脏骤停（CA）是发病率和死亡率的主要原因。这些损伤对中枢神经系统的损伤是不良结果的关键决定因素。这些神经系统和多系统的损害需要多学科和多部门的反应，必须从现场到康复进行协调。儿科神经重症监护和复苏的研究培训最好由并行的多学科和多部门计划提供。我们在萨法尔复苏研究中心的独特博士后项目，自2000年以来得到T32的支持，建立了跨脑损伤婴儿和儿童连续护理的重要联系，并促进了跨关键学科的严格科学研究，包括儿科重症医学、儿童神经病学、儿科神经外科、儿科急诊医学、新生儿学、儿科放射学、物理医学和康复。我们培训这些儿科学科的研究员进行神经重症监护和复苏的基础和临床研究，将他们与资深科学家联系起来。在这个竞争性的更新申请中，每年要求资金支持4个职位。自成立以来，该计划已经填补了每个职位的高素质研究员，他们发表了许多同行评审的论文和摘要，并获得了许多奖项。在上一个资助周期中，6名毕业生中有4名已获得5项K奖（2名k12、2名k08、1名K23）；许多人都获得了高等学位。他们作为教员受到高度追捧；他们都是学术职位。研究重点是损伤机制、新疗法和TBI和CA后的结果。我们采用由联邦政府资助的教师研究支持的从实验室到床边的方法。我们充分利用萨法尔中心与匹兹堡儿童医院和匹兹堡大学医学院的培训项目之间的独特互动，并利用许多独特资源和临床与转化科学研究所的优势。主任、联合主任和导师都是敬业、合格的科学家和经过验证的教育工作者。每个导师的研究领域提出重要的问题，适合职业发展和假设检验。我们整合了神经重症监护课程，并参与了独特的儿科神经重症监护临床服务。毕业生可以制定、执行、分析、展示和发表旨在回答关键问题的实验，并接受资助和研究诚信方面的培训。该项目在多元化招聘方面取得了成功，特别是在招聘残疾申请人方面。

DESCRIPTION (provided by applicant): Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi- system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is best served by a parallel multidisciplinary and multi- departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation. We train fellows in these pediatric disciplines in basic and clinical research in neurointensive care and resuscitation, linking them to senior scientists. In this competitive renewal application, funds are requested to support 4 positions each yr. Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many awards. In the last funding cycle, 4 of the 6 graduated fellows have already acquired 5 K awards (two K12s, two K08s, and one K23); many have received advanced degrees. They are highly sought after as faculty; all are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. We use a bench-to-bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Medicine and also take advantages of many unique resources and a Clinical and Translational Science Institute. The director, co-director, and mentors are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a unique pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions and are trained in grantsmanship and research integrity. The program has had success in diversity recruitment, notably, in recruiting applicants with disabilities.