7T Magnetic Resonance Imaging System for Basic, Translational and Clinical Research

项目总结 康奈尔大学威尔医学院(Weill Cornell Medicine，WCM)要求高端仪器 授予计划支持购买最先进的人类全身7特斯拉(7T)磁铁 作为特殊用途的磁共振成像(MRI)系统(SUI；PAR-19-177)。这款7T核磁共振是 对关键的成像基础设施进行重大的WCM战略投资，以推动基础、转换和 临床研究。AS超高场7T为MRI研究提供最高的信噪比(SNR)和最高 用于组织磁性研究的信号，两者都随着MRI场强的增加而增加，7T MRI是一种重要的研究工具 为我们的用户研究毁灭性的疾病，在重要的大脑和许多其他器官的微妙的病理 尸体。我们要求这款SUI 7T磁共振成像具有最高的临床可用磁场强度，用于集成生物医学 研究和临床实践，其中临床实践将有助于克服高昂的购买成本， 安装、操作和维护7T核磁共振，更重要的是，将提高转换和临床 研究是我们大多数用户关注的焦点。WCM是生物医学研究的世界领先者，其长期的 范围目标包括在疾病的早期阶段捕获和治愈疾病。这款SUI 7T MRI，拥有精致的组织 在疾病进展和治疗反应的早期阶段发现细微变化的敏感度将有助于 对我们了解和治疗各种疾病，包括神经退行性变， 精神疾病、癫痫、中风、骨关节炎、炎症性疾病、癌症和血管疾病。

PROJECT SUMMARY Weill Medical College of Cornell University (Weill Cornell Medicine, WCM) requests High-End Instrumentation Grant Program support to purchase a state-of-the-art human whole-body seven Tesla (7T) magnetic resonance imaging (MRI) system as a Special Use Instrument (SUI; PAR-19-177). This 7T MRI is part of a major WCM strategic investment in crucial imaging infrastructure needed to advance basic, translational and clinical research. As ultrahigh field 7T offers supreme signal-to-noise ratio (SNR) for MRI studies and supreme signal for tissue magnetism studies, both that increase with MRI field strength, 7T MRI is a vital research tool for our users to study devastating diseases of subtle pathologies in the vital brain and many other organs in the body. We request this SUI 7T MRI of the highest clinically-available field strength for integrated biomedical research and clinical practice, where the clinical practice will help overcome the prohibitive cost of purchasing, installing, operating and maintaining a 7T MRI and, more importantly, will enhance translational and clinical researches that are the foci of most our users. WCM is a world leader on biomedical research, and its long- range goals include catching and curing diseases at their early stages. This SUI 7T MRI, with exquisite tissue sensitivity to detect subtle changes at early stage of disease progression and therapy response, will contribute significantly to our quest in understanding and treating various diseases, including neurodegeneration, psychiatric disorders, epilepsy, stroke, osteoarthritis, inflammatory diseases, cancers, and vascular diseases.