Fernald Community Cohort: Research Resource for Environmental Epidemiology

费尔纳德社区队列(FCC)由参加费尔纳德医疗的9782人组成 1990-2008年的监测计划(FMMP)。FMMP是一项为期18年的医疗监测计划， 居住在前美国能源部费尔纳德铀加工厂附近的社区居民 辛辛那提)，俄亥俄州。虽然符合条件的FMP是基于居住在工厂5英里以内的，但大部分 队列中从未受到超过普通人群接受的本底暴露的辐射暴露。 在考试计划结束时，这项研究被重新命名为费尔纳德社区队列(FCC)。这 Cohort欣然接受了环境健康发现的复杂性。暴露的多个组成部分是 通过问卷采集数据和接触途径建模。大量采集的血液和 在18年期间获得的尿液生物检疫可以用来测量暴露，早期生物 影响和疾病生物标志物，以及准确分配的定期全面体检 表型。这一队列可用于研究广泛的暴露及其健康后果。联邦通信委员会 有一个既定的程序来提供对数据和生物制品的访问，这些数据和生物制品已经被广泛分享 并已用于80项研究，在同行评议期刊上发表了35篇手稿。 在这个修订的应用程序中，我们结合了生物医学信息学的专业知识来转换为代码标准 本体，创建FCC元数据的新门户，并将我们的元数据存储到NIH和其他 储存库。我们的生物医学信息学团队将开发一个新的在线门户，供调查人员探索 FCC个人数据和元数据(FCCPortal)，这也将提高我们管理资源的效率 分享。我们建议： 目标1：通过更新健康状况，在保持队列的同时增加对科学界的价值 信息，招募800名“下一代”队列成员并收集他们的数据和生物标本， 通过定期质量保证评估维护我们的生物信息库，并增加通信队列 与会员和社区医生分享我们的研究活动和发现。 目标2：通过获得新的健康结果和暴露数据来丰富队列，将我们的代码转换为 医学术语、诊断和药物到标准本体，开发新的生物医学信息学 工具和探索在新技术中使用银行样本的可行性(ccfDNA用于DNA 甲基化生物标记；外体miRNA用于表达分子标记)。 经过25年的跟踪，FCC是一个基本的研究资源。资源被很好地记录下来， 包括一个提供详细信息的网站、可搜索的数据词典和大量的生物制品清单 数据库。在NIEHS的资助下，我们将能够保持这一宝贵的资源，并增加其 队列在调查暴露的世代影响方面的价值，并为其他研究项目服务。

The Fernald Community Cohort (FCC) consists of the 9782 persons who participated in the Fernald Medical Monitoring Program (FMMP) from 1990-2008. The FMMP was an 18-year medical surveillance program for community residents living near the former US Department of Energy uranium processing site at Fernald (near Cincinnati), Ohio. Although eligibility for the FMMP was based on living within 5 miles of the plant, much of the cohort never received radiation exposure beyond the background exposure received by the general population. At the end of the examination program, the study was renamed the Fernald Community Cohort (FCC). This cohort embraces the complexity of discovery in environmental health. Multiple components of the exposure are captured through the questionnaire data and exposure pathway modeling. The large collection of blood and urine biospecimens obtained throughout the 18-year period can be used to measure exposure, early biologic effects and disease biomarkers, and the periodic comprehensive medical examinations accurately assigned phenotype. This cohort can be used to study a wide range of exposures and their health outcomes. The FCC has an established procedure for providing access to data and biospecimens, which have been shared widely and have been used in 80 research studies, resulting in 35 manuscripts published in peer-review journals. In this revised application, we incorporate biomedical informatics expertise to convert to codes standard ontologies, create new portals to FCC metadata, and deposit our meta data into the NIH and other repositories. Our Biomedical Informatics team will develop a new online portal for investigators to explore the FCC individual and meta data (FCCPortal), which will also increase our efficiency in managing resource sharing. We propose to: Aim 1: Maintain the cohort while increasing the value to the scientific community, by updating health status information, enrolling 800 “next generation” of cohort members and collecting their data and biospecimens, maintain our biorepository with periodic quality assurance assessments, and increase communication cohort members and with community physicians regarding our research activities and findings. Aim 2: Enrich the cohort through obtaining new health outcome and exposure data, converting our codes for medical terms, diagnoses, and medications to standard ontologies, developing new biomedical informatics tools and by exploring the feasibility of using banked samples in new technologies(ccfDNA for DNA methylation biosmarkers; exosomal miRNA for expression molecular markers). After 25 years of follow-up, the FCC is a primed research resource. Resources are well documented, including a website with detailed information, searchable data dictionary, and extensive biospecimen inventory database. With funding from NIEHS, we will be able to both maintain this valuable resource and increase its value of the cohort for investigating generational effects of exposures, and serve additional research projects.