Shanghai Men's Health Study

描述（由申请人提供）：上海男性健康研究（SMHS）自2001年起由NCI资助（R0I CA082729），是一项基于人群的队列研究，在2002年至2006年期间招募了61,491名男性，并通过多次亲自随访调查和记录联系进行了随访。多年来，在SMHS中收集的数据和生物样本已用于评估许多重要的病因假设并支持多项研究，包括超过25个联盟项目。为了维持和扩大其资源和成功，我们正在申请基础设施资金，其具体目标如下：1)继续对该队列进行癌症发病率和特定原因死亡率的随访，并通过进行面对面访谈来扩大该队列的资源，以更新有关暴露和选定疾病结局的信息；2)维护SMHS的数据库和生物库，实施质量控制方案，使其资源价值最大化用于科学研究；3)收集6000名研究参与者的血液和尿液样本，以增强我们研究中间疾病生物标志物的能力，这是在基线和随后的随访中评估暴露的结果；4)通过检索覆盖研究人群的电子健康信息系统数据库，收集队列成员常见慢性病的诊断和治疗相关信息；5)收集肺癌、胃癌、结肠/直肠癌、肝癌和前列腺癌（队列中最常见的五种癌症）患者的肿瘤组织样本和癌症治疗、复发和生存的详细信息，收集胃癌、结肠/直肠癌和前列腺癌幸存者的诊断后生活方式因素和生活质量信息；6)。建立一个网站，以促进和促进更广泛的癌症研究人员之间的合作，传播研究成果，吸引和培养新的研究人员。SMHS样本量大，资源丰富，暴露模式和疾病谱系独特，为解决许多重要假设提供了绝佳的机会，而这些假设在任何其他现有队列研究中都无法得到充分调查。继续对该队列进行随访并扩大其资源，将进一步增加SMHS对癌症和其他慢性病的长期流行病学研究的价值。

DESCRIPTION (provided by applicant): The Shanghai Men's Health Study (SMHS), funded by NCI since 2001 (R0I CA082729), is a population based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed through multiple in-person follow-up surveys and record linkages. Over the years, data and biological samples collected in the SMHS have been used to evaluate many important etiologic hypotheses and support multiple studies, including over 25 consortium projects. To both sustain and expand its resources and success, we are applying for infrastructure funding with the following specific aims: 1) Continue the follow-up of this cohort for cancer incidence and cause-specific mortality and expand the cohort's resources by conducting in-person interviews to update information on exposures and selected disease outcomes; 2) Maintain the data bank and biorepository of the SMHS and implement quality control protocols to maximize the value of its resources for scientific research; 3) Collect blood and urine samples from 6,000 study participants to enhance our ability to study intermediate disease biomarkers as a consequence of exposures assessed at the baseline and subsequent follow-ups; 4) Collect information related to the diagnosis and treatment of common chronic diseases for cohort members by searching the database of an electronic Health Information System covering the study population; 5) Collect tumor tissue samples and detailed information on cancer treatment, recurrence, and survivorship for participants diagnosed with cancers of the lung, stomach, colon/rectum, liver, and prostate, the five most common cancers in the cohort, as well as collect post-diagnosis lifestyle factor and quality of life information for survivors of stomach, colon/rectum, and prostate cancer; 6).To build a website to promote and facilitate collaborations among the broader community of cancer researchers, to disseminate research findings, and to attract and cultivate new investigators. The SMHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in any other existing cohort study. Continuing follow-up of the cohort and expansion of its resources would further increase the value of the SMHS for a long-term epidemiologic study of cancer and other chronic diseases.