Epidemiology of Age-related Macular Degeneration and Other Retinal Diseases - Enrollment Center

老年性黄斑变性等视网膜疾病的流行病学研究 项目摘要/摘要 这项建议建立在对参与海狸水坝眼的人的纵向队列研究的基础上 研究(BDES)，由国家眼科研究所拨款U10 EY006594资助。这项研究包括了年龄在43-86岁的人 他们居住在威斯康星州海狸大坝的城镇，这些人是在1987年的一次私人人口普查中确定的- 88并在1988-1990年和此后每5年检查一次。在每次检查中，年龄相关性黄斑 通过立体眼底照相对变性(AMD)和其他视网膜疾病进行分级，并 测量屈光度和视力。这将在25年的后续行动中完成。光谱域光学 相干断层扫描(SD-OCT)是一种非侵入性的定量方法，用于测量视网膜厚度和 记录眼底照相和倍频未观察到的其他解剖特征 在20年的随访中增加了技术(FDT)视野检查。我们将测量皮肤的本征荧光 (SIF)、血清晚期糖基化终产物(AGEs)、AGEs的可溶性受体(S-RAGE)和氧化 低密度脂蛋白胆固醇(OX-LDL)，氧化应激的标志，在拟议的25年随访中 考试。此外，我们将从以前收集的冷冻血清中检测AGEs和ox-ldl。 检查以确定它们与25岁以上AMD的发病和进展的纵向联系 多年的研究，以及炎症标记物、亚临床动脉粥样硬化和候选基因如何 更改关联。我们将研究这些措施在AMD风险评估中的效用。 我们还将研究SIF与AMD的患病率和严重程度的关系，以及 SD-OCT和FDT视野检查所确定的视网膜形态对AMD 5年发病和进展的影响 通过彩色眼底照片测量，以及上述新发现的 测定视网膜病变和白内障的分析结果。发现和描述具有先兆作用的视网膜特征 通过SD-OCT对AMD最早病变的发展将允许及时干预脱轨或 预防AMD的发展。这项研究的新数据将提供一个独特的机会来研究 非酶糖化和氧化应激在AMD发病机制中的作用不受年龄的影响 吸烟状况和高危遗传标记。

Epidemiology of Age-Related Macular Degeneration and Other Retinal Diseases Project Summary/Abstract This proposal builds on a longitudinal cohort study of persons participating in the Beaver Dam Eye Study (BDES), funded by National Eye Institute grant U10 EY006594. The study included persons aged 43-86 years living in the city and township of Beaver Dam, Wisconsin who were identified in a private census in 1987- 88 and were examined in 1988-1990 and every 5 years thereafter. At each examination, age-related macular degeneration (AMD) and other retinal diseases were graded from stereoscopic fundus photography, and refraction and visual acuity were measured. This will be done at the 25 year follow-up. Spectral domain optical coherence tomography (SD-OCT), a noninvasive, quantitative method used to measure retinal thickness and to document other anatomic features not observed with fundus photography, and frequency doubling technology (FDT) perimetry were added at the 20-year follow-up. We will measure skin intrinsic fluorescence (SIF), serum advanced glycation endproducts (AGEs), a soluble receptor for AGEs (s-RAGE), and oxidized low-density lipoprotein cholesterol (ox-LDL), a marker of oxidative stress, at the proposed 25-year follow-up examination. In addition, we will measure AGEs and ox-LDL from frozen serum collected at previous examinations to determine their longitudinal associations to the incidence and progression of AMD over the 25 years of study, as well as how markers of inflammation, subclinical atherosclerosis and candidate genes may alter the associations. We will examine the utility of these measures for risk assessment of developing AMD. We will also examine the relationships of SIF with the prevalence and severity of AMD, the relationships of retinal morphology identified by SD-OCT and FDT perimetry to the 5-year incidence and progression of AMD as measured by color fundus photographs, and the longitudinal relationships of the aforementioned newly measured analytes to retinopathy and cataract. Discovering and describing retinal features that are harbingers of the development of the earliest lesions of AMD through SD-OCT will permit timely intervention to derail or prevent the development of AMD. The new data from this study will provide a unique opportunity to examine the role of nonenzymatic glycation and oxidative stress in the pathogenesis of AMD independent of age, smoking status, and high-risk genetic markers.