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Effects of redox homeostasis on cancer and cardiovascular diseases

Effects of redox homeostasis on cancer and cardiovascular diseases
氧化还原稳态对癌症和心血管疾病的影响
批准号：
9157381
负责人：
PAUL M. HWANG
金额：
$59.03万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9157381
关键词：
AerobicAffectBiologicalBiologyCardiovascular DiseasesCardiovascular systemCell modelCellular StressDNA DamageDevelopmentDiseaseEnergy MetabolismGeneticGenomic DNAHealthHomeostasisHumanLifeMalignant NeoplasmsMethodsMitochondriaNuclearOxidation-ReductionOxygenPathogenesisReactive Oxygen SpeciesStressmitochondrial dysfunctionmouse modelneoplastic cellpreventtumorigenesis

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中文摘要
翻译
我们以前的研究表明，线粒体功能障碍导致氧化基因组DNA损伤，并有助于肿瘤的发生。 氧是有氧生活所必需的，但它也是活性氧的基本基质，可导致生物损伤。 我们目前正在使用环境和遗传的方法来调节氧稳态，并检查其对能量代谢，肿瘤发生和心血管疾病的影响。 我们也在研究肿瘤或心血管起源的细胞在氧化或其他毒性应激条件下生存的适应机制。
英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. Oxygen is necessary for aerobic life but it also serves as the essential substrate for reactive oxygen species that can cause biological damage. We are currently using environmental and genetic methods to modulate oxygen homeostasis and to examine their effect on energy metabolism, tumorigenesis, and cardiovascular disease. We are also examining adaptive mechanisms by which cells of neoplastic or cardiovascular origin survive under oxidative or other toxic stress conditions.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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