Musculoskeletal and Finite Element Modeling of Femoroacetabular Impingement

描述（由申请人提供）：股骨髋臼撞击（FAI）是髋关节间隙减少，导致髋关节疼痛，并可能使髋关节易患骨关节炎（OA）。生物力学的改变被认为是OA的关键引发因素。FAI患者常表现为软骨盂唇损伤和活动范围受限，表明FAI改变了软骨/盂唇接触力学和髋关节运动学。最近的研究表明，FAI也可能导致肌肉激活和力量的主要或适应性变化。 以往的临床和基础生物力学研究未能阐明FAI之间的联系，改变生物力学和OA由于过于简单的方法或不准确的测试设备。我们的长期目标是通过量化髋关节生物力学来改善FAI的诊断和治疗。为了支持这一目标，我们提出了一个R21级的研究，以证明使用相结合的实验和计算协议，以量化关节运动学，肌肉力量/激活，和软骨/盂唇接触力学在人类髋关节的可行性。 我们将使用双重荧光透视和基于摄像头的标记跟踪相结合，以量化日常生活活动中的下肢运动学。肌肉骨骼（MS）模型将估计肌肉力/激活，有限元（FE）模型将预测软骨盂唇力学。在过去，我们的MS模型假设静态髋关节中心和预定义的肌肉附件，我们的FE模型假设文献中的边界和载荷条件。在本R21中，我们将比较特定于主题的模型与假设预定义或基于文献的输入的模型之间的MS模型（目标1）和FE模型（目标2）预测。 在确定所需的模型复杂性水平并对R21的试验数据进行功率分析后，我们将寻求R 01级资金，扩展我们的计算和实验方案，以进一步研究FAI的生物力学。

DESCRIPTION (provided by applicant): Femoroacetabular impingement (FAI) is a reduction in hip joint clearance that causes hip pain and may predispose the hip joint to osteoarthritis (OA). Altered biomechanics are considered the key initiator of OA. Patients with FAI often present with chondrolabral damage and restrictions in range of motion, suggesting that FAI alters cartilage/labrum contact mechanics and hip kinematics. Recent studies suggest that FAI may also cause primary or adaptive changes to muscle activation and force. Previous clinical and basic biomechanics studies have failed to elucidate the link between FAI, altered biomechanics and OA due to oversimplified approaches or inaccurate testing equipment. Our long term goal is to improve the diagnosis and treatment of FAI by quantifying hip biomechanics. To support this goal, we propose a R21-level research study to demonstrate the feasibility of using a combined experimental and computational protocol to quantify joint kinematics, muscle forces/activations, and cartilage/labrum contact mechanics in the human hip. We will use a combination of dual fluoroscopy and camera-based marker tracking to quantify lower limb kinematics during activities of daily living. Musculoskeletal (MS) models will estimate muscle forces/activations and finite element (FE) models will predict chondrolabral mechanics. In the past, our MS models assumed a static hip joint center and pre-defined muscle attachments and our FE models assumed boundary and loading conditions from the literature. In this R21, we will compare MS model (Aim 1) and FE model (Aim 2) predictions between models that are subject-specific with those that assume pre-defined or literature-based inputs. After determining the required level of model complexity and after conducting power analyses with the pilot data from this R21, we will pursue R01 level funding extending our computational and experimental protocols to further investigate the biomechanics of FAI.