Enabling Data Science in Biology

 描述(由申请者提供)：本提案的目的是开发、试行测试并提供新的开放获取模块教育课程，从而实现生物学中的数据科学(EDSB)。EDSB将涵盖开发和管理完整数据管道的概念、方法和要求，以建立和管理由大型数据提供者社区提供的经过管理的生物实验数据公共档案。负责开发和提供eDSB课程的项目主任和项目系由来自生物信息学研究合作实验室(RCSB)高级人员的经验丰富的结构生物学家、数据科学家和教育工作者组成。RCSB开发和管理一系列数据资源，包括蛋白质数据库(PDB，与国际合作伙伴)、EMDataBank(与国际合作伙伴)、结构生物学知识库和核酸数据库，并开发教育材料和课程，以促进数据资源的使用。在结构生物学领域迅速扩张的过程中，RCSB为这些数据资源建立了基础设施，并在过去20年里成功地管理了它们。EDSB将根据RCSB团队积累的丰富经验，为数据资源管理提出最佳做法建议。RCSB团队非常有动力将其知识转移给新的数据资源构建者和提供商。EDSB的目标受众包括图书管理员和信息专家，他们将能够使用这些材料作为其组织提供的培训和服务的基础，以及用于自学的科学家。此外，eDSB课程将使RCSB及其国际合作伙伴能够促进拟议的模型和数据档案联邦系统的形成，这将加速综合结构生物学领域的进展。EDSB课程将分为八个模块，既可以单独学习，也可以组合成一套完整的在线开放课程。

 DESCRIPTION (provided by applicant): The aim of this proposal is to develop, pilot test, and deliver a new open access modular educational curriculum, Enabling Data Science in Biology (eDSB). eDSB will cover concepts, approaches and requirements for developing and managing the full data pipeline for a curated public archive of biological experimental data contributed by large community of data providers. The Program Director and Program Faculty responsible for developing and delivering the eDSB curriculum are experienced structural biologists, data scientists, and educators drawn from the senior ranks of the Research Collaboratory for Bioinformatics (RCSB). The RCSB develops and manages a number of data resources including the Protein Data Bank (PDB, with international partners), EMDataBank (with international partners), the Structural Biology Knowledgebase, and the Nucleic Acid Database, and develops educational materials and curricula to promote data resource usage. The RCSB built the infrastructure for these data resources and has successfully managed them over the past 20 years, during the course of a rapid expansion in the area of Structural Biology. eDSB will make best practices recommendations for data resource management based on the extensive experience accumulated by the RCSB team. The RCSB team is highly motivated to transfer its knowledge to new data resource builders and providers. The intended eDSB audience includes librarians and information specialists, who will be able to use the materials as a basis for training and services offered by their organizations, and scientists for self-instructin. In addition, the eDSB curriculum will allow the RCSB and its international partners to catalyze formation of a proposed federated system of model and data archives that will accelerate progress in the realm of Integrative Structural Biology. The eDSB curriculum will be divided into eight Modules that can either be studied separately or assembled into a complete set as an open online course.