Whole Body Vibration Training for Healthy Body Composition in Young Adults

描述(申请人提供)：年轻人(18-24岁)特别容易发生身体成分的不健康变化(平均体重增加30磅)，这使他们容易患上与肥胖有关的疾病。这项拟议的研究旨在检验这一新的假设，即积极参与全身振动(WBV)训练将导致抑制脂肪积累，维持精瘦肌肉质量，并降低与肥胖相关的危险因素水平。WBV包括一种独特的方法，通过传递高频、低幅度的机械信号来刺激肌肉骨骼系统。根据我们的初步数据和发表的研究结果，假设在6个月结束时，与分配给对照组的人相比，接受20分钟WBV 3d/wk的年轻人不会经历体重增加，而是保持精瘦的肌肉质量。这一假设是基于我们强有力的初步研究，在这些研究中，我们已经表明，重复暴露于WBV可以减少成年大鼠与年龄相关的脂肪质量增加，同时保持精瘦的肌肉质量。在老年人中的其他初步发现表明，WBV干预在保持瘦体重的同时有效地减少身体质量、脂肪质量和身体脂肪百分比。在拟议的研究中，将进行为期6个月的随机对照试验，包括两组：1)WBV组和2)注意力控制放松组，通过以下目的来检验这一假说：评估实施全身振动(WBV)运动训练计划作为预防身体不活跃的年轻人(18-24岁)体重增加和脂肪量增加的方法的疗效和可行性。主要观察指标包括：总体重、体脂百分比、脂肪质量、内脏脂肪组织和脱脂质量，用双能X线吸收法(DXA)测量。这项拟议的研究具有潜在的创新性，因为它利用了一种新的治疗技术-WBV，通过被动应用高频、低幅度的机械信号来刺激肌肉骨骼系统，从而改善身体成分。这项拟议研究的成功完成将使WBV训练成为一种安全可行的计划，具有很高的依从性和可接受性，可以预防年轻人的体重增加。在6个月结束时，青壮年接受20分钟的治疗。WBV 3D/WK的人将保持他们的体重，并将拥有更健康的身体成分(瘦脂肪质量)。这项申请符合NIH的战略目标，即鼓励探索性/发展性临床研究，以加速开发有效的干预措施，预防或治疗成人和/或儿童超重和/或肥胖，PA-09-124肥胖症探索性/发展性临床研究补助金(R21)。这种新的和实质性的不同方法预计将克服招募、留住和激励年轻人保持体重稳定的困难，通常与其他长期体重计划有关，从而产生一种有效的体重增加预防方法。好了！

DESCRIPTION (provided by applicant): Young adults (18-24 years) are particularly prone to unhealthy changes in body composition (average weight gain 30 pounds) that predispose them to development of obesity-related diseases. The proposed research is designed to test the novel hypothesis that active participation in whole-body vibration (WBV) training will result in suppression of accumulation of fat, maintenance of lean muscle mass and reduced levels of risk factors as- sociated with obesity. WBV involves a unique method of stimulating the musculoskeletal system through pas- sive application of high frequency, low amplitude mechanical signals. Based upon our preliminary data and published findings, it is hypothesized that, at the end of 6-months, young adults receiving a 20-minute of WBV 3 d/wk, will not experience weight gain but will instead maintain lean muscle mass compared to those assigned to the control group. This hypothesis is based on our strong preliminary studies, in which we have shown that repeated exposure to WBV reduced age-related increases in fat mass in mature rats while maintaining lean muscle mass. Additional preliminary findings in older adults suggest a WBV intervention to be effective in re- ducing body mass, fat mass and percent body fat while maintaining lean mass. In the proposed study, a 6- month randomized controlled trial will be carried out with two groups: 1) WBV and 2) attention control relaxa- tion group, to test th hypothesis by through the following Aim: To evaluate the therapeutic benefits and feasi- bility of implementing a whole-body vibration (WBV) exercise training program as a method of preventing weight gain and increases in fat mass in physically inactive young adults (18-24 yrs.). Primary outcome meas- ures include: Total body weight, % body fat, fat mass, visceral adipose tissue, and fat free mass, measured by dual energy X-ray absorptiometry (DXA). The proposed study is potentially innovative because it capitalizes on a new therapeutic technique - WBV to improve body composition by stimulating the musculoskeletal system through the passive application of high frequency, low amplitude mechanical signals. Successful completion of the proposed research would establish WBV training as a safe and feasible program with high compliance and acceptability for preventing weight gain in young adults. At the end of 6-months, young adults receiving a 20- min. of WBV 3d/wk will have maintained their body weight and will have a healthier body composition (lean-fat mass). This application addresses the NIH strategic goal to encourage exploratory/developmental clinical re- search that will accelerate development of effective interventions for prevention or treatment of overweight and/or obesity in adults and/or children and, PA-09-124 Exploratory/Developmental Clinical Research Grants in Obesity (R21). This new and substantively different approach is expected to overcome difficulties of recruiting, retaining, and motivating young adults to remain weight stable, often associated with other long term weight programs, thereby resulting in an efficacious approach to weight gain prevention. !