2nd International Symposium on Collaterals to the Brain

简介(申请人提供)：第二届脑络脉国际研讨会是一个多学科的科学会议，重点研究急性和慢性脑血管疾病的侧支循环灌注。 慢性神经血管疾病。这项提议要求部分支持一个具有广泛、长期目标的会议，该会议将推进当前关于侧支循环的研究，确定差距，并就与中风侧支相关的关键话题达成共识声明。在这一努力中指导初级调查人员是这次专门讨论大脑络脉的独特会议的一个主要重点。在几乎所有的急性和慢性脑缺血疾病中，脑的侧支循环灌注被认为是卒中风险、缺血性脑梗塞和再灌注损伤的基本决定因素，包括出血性转化、恢复和临床结果。这个论坛的设立是为了关注NINDS的这一首要研究重点。本次会议的目标是召集超过48位顶尖专家讨论这一新兴领域的关键方面，共有400名与会者参加为期两天的学术会议。确认的计划被组织成12个关于反向工程抵押的一小时辩论主题，支持系统生物学方法。由2名专家组成的团队将利用公开论坛辩论的形式有条不紊地达成共识，最终发布一份关于侧支循环研究的详细共识声明。由主持人主持的关于反向指导的晚宴研讨会将反思研讨会期间讨论的6个主题，6名被提名获得旅行奖学金的初级调查人员将涵盖这些主题。将尽一切努力鼓励研究生和博士后参与，使妇女人数均等，并将少数群体和残疾人包括在内。将评估会议目标的可衡量结果，评估这次研讨会对NIH对新研究人员的承诺、转化性卒中研究以及NINDS PRG侧支灌流研究的优先顺序的影响。通过一次独特的活动、相关的互动和随后发表的共识声明，培育新的研究合作框架、指导新的研究人员和改进这一领域的临床实践，突显了这一建议的重要性。这项建议与健康相关的基础是讨论和研究计划，这些讨论和研究计划解决了侧支在破坏性的中风紊乱中的重要作用的关键优先事项。

DESCRIPTION (provided by applicant): The 2nd International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. This proposal requests partial support for a conference with broad, long-term objectives that will advance current research on collateral perfusion, identify gaps and produce a consensus statement on critical topics related to collaterals in stroke. Mentoring junior investigators in this endeavor is a major emphasis of this unique meeting devoted to collaterals to the brain. Collateral perfusion of the brain is now recognized as a fundamental determinant of stroke risk, ischemic infarction, and reperfusion injury including hemorrhagic transformation, recovery and clinical outcome in virtually every acute and chronic ischemic disorder of the brain. This forum has been established to devote attention to this top research priority of NINDS. The aims of this conference will convene over 48 leading experts to debate critical aspects of this burgeoning field, with a total of 400 participants for a 2-day conference in an academic setting. The confirmed program is structured into 12 one-hour debate topics on reverse engineering collaterals, endorsing a systems biology approach. Public forum debate format will be utilized by teams of 2 experts to methodically reach consensus, culminating with publication of a detailed consensus statement on research in collateral perfusion. A moderated dinner seminar on reverse mentoring will reflect upon the 6 themes addressed throughout the symposium, covered by 6 junior investigators nominated for travel scholarships. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. Measurable outcomes of conference goals will be assessed, evaluating the impact of this symposium on the NIH commitment to new investigators, translational stroke research and the NINDS PRG priority for studies on collateral perfusion. The significance of this proposal is underscored by the cultivation of a framework for novel research collaborations, mentoring of new investigators and improved clinical practice in this area, through a unique event, associated interactions and subsequent publication of a consensus statement. The health relatedness of this proposal is rooted in the discussions and research initiatives that address key priorities on the influential role of collaterals in the devastating disorder of stroke.