Hispanic Satellite Core

核心F：西班牙裔卫星-摘要 2010年，美国约有4600万拉美裔美国人。西班牙裔老年人有患痴呆症的风险，原因是 阿尔茨海默病(AD)和血管危险因素。加州大学圣迭戈分校ADRC对衰老和痴呆的研究 旨在提高我们对阿尔茨海默病和相关疾病的理解并克服障碍 对早期(甚至临床前)疾病的有效评估、诊断和治疗。人造卫星将 支持衰老和痴呆症的一般研究，因为受试者将经历相同的程序， 包括生物标记物研究和尸检同意请求，作为ADRC的非西班牙裔受试者，以及 将为研究项目和临床试验做出贡献。此外，该卫星还将支持对 拉美裔独有的方面，包括1)双语和低教育程度对诊断的影响 评估和认知储备与痴呆症风险；2)遗传、血管和社会经济风险 认知衰退和痴呆症的因素。 拉美裔卫星在此次ADRC续签申请中的总体目标是： 1)通过招募和跟踪具有良好特征的西班牙裔受试者来支持研究工作 认知、轻度认知障碍(MCI)和AD。卫星将跟踪大约100名受试者( 继续招募与死亡和辍学之间的平衡)。受试者将接受标准的临床试验 表征(包括统一数据集程序)。生物样本(DNA、血浆和脑脊液)， 将获得核磁共振和其他脑部图像。将维持一个全面的数据库。研究对象将 在死后继续为尸检研究做出贡献。数据、生物样本和脑成像研究来自 西班牙裔卫星受试者将与来自非拉美裔美国人的受试者整合，随后是临床核心。 2)与加州大学圣迭戈分校、退伍军人医学中心和附近研究机构的研究人员广泛互动。在……里面 特别是，支持正在资助的关于双语以及脑成像和认知的研究 年龄变化与载脂蛋白E基因和血管危险因素的关系。 4)向国家阿尔茨海默氏症协调中心提供数据，向NCRAD提供DNA，并与 其他AD中心，以及与AD和痴呆症相关的多中心研究工作。主题将是 参与阿尔茨海默病合作研究(ADCS)组织的临床试验， 主要由遗传性阿尔茨海默病网络(DIAN)和制药公司提供。 5)继续支持创新研究和培训新的调查人员， 6)促进专业教育和培训，提高公众对老龄化的认识和认识， 影响认知健康的血管和其他危险因素在西班牙裔人中的老化和痴呆风险。 为受AD影响的患者和家庭提供创新的支持努力。

CORE F: HISPANIC SATELLITE - ABSTRACT There were about 46 million Hispanics in the USA in 2010. Elderly Hispanics are at risk for dementia, due to Alzheimer's Disease (AD) and vascular risk factors. The UCSD ADRC's studies of aging and dementia among Hispanics aim to improve our understanding of AD and related disorders and to overcome barriers to effective assessment, diagnosis and treatment of early (and even preclinical) disease. The Satellite will support general research in aging and dementia, because subjects will undergo the same procedures, including biomarker studies and request for autopsy consent, as non-Hispanic subjects in the ADRC, and will contribute to research projects and clinical trials. In addition, the Satellite will support research into aspects unique to Hispanics, including 1) the influence of bilingualism and low education on diagnostic assessment and in cognitive reserve and dementia risk; 2) genetic, vascular, and socio-economic risk factors for cognitive decline and dementia. Overall aims for the Hispanic Satellite in this ADRC renewal application are to: 1) Support research efforts by recruiting and following well-characterized Hispanic subjects with normal cognition, Mild Cognitive Impairment (MCI), and AD. The Satellite will follow about 100 subjects (the balance between continued recruitment and death and dropout). Subjects will undergo standard clinical characterization (including the Uniform Data Set procedures). Biological samples (DNA, plasma and CSF), MRI and other brain images will be obtained. A comprehensive database will be maintained. Subjects will continue to contribute to autopsy studies after death. Data, biosamples and brain imaging studies from Hispanic Satellite subjects will be integrated with those from non-Hispanics followed by the Clinical Core. 2) Interact widely with researchers at UCSD, the VA Medical Center, and nearby research institutions. In particular, support ongoing funded research studies on bilingualism and on brain imaging and cognitive changes in aging in relation to APOE genotype and vascular risk factors. 4) Provide data to the National Alzheimer's Coordinating Center, and DNA to NCRAD, and collaborate with other AD Centers, and with multi-Center research efforts related to AD and dementia. Subjects will be offered participation in clinical trials organized by the Alzheimer's Disease Cooperative Study (ADCS), the Dominantly Inherited Alzheimer Network (DIAN), and by pharmaceutical companies. 5) Continue to support innovative research and train new investigators, 6) Foster professional education and training, and to improve public knowledge and awareness about aging, vascular and other risk factors that influence cognitive health in aging and dementia risk among Hispanics. To provide innovative support efforts for patients and families affected by AD.