Console and gradient upgrade for a 9.4 T 16 cm in vivo MR system

 描述(申请人提供)：耶鲁大学MRRC是使用1H、13C MRS和超高分辨率功能磁共振成像研究小动物模型新陈代谢和功能的先驱和领先网站。MRRC的9.4T 21厘米动物系统自2004年安装以来一直是这些研究的主力。目前，它支持美国国立卫生研究院资助的22名耶鲁大学和其他机构教职员工的研究，其中包括9名主要用户。NIH对用户组的支持是25个奖项，包括2个中心拨款(P30，U24)，1个P01，18个R01，1个DP1奖，1个R21和2个K奖。它是耶鲁大学NINDS P30 MR核心中心和NIDDK小鼠代谢表型中心的主要资源。然而，新的磁共振方法和突破性的疾病应用程序的持续开发，一直是该系统研究计划的标志，但由于其已有7年历史的安捷伦游戏机和已有10年历史的GRADER硬件的限制，这一点受到了严重影响。此外，随着安捷伦退出MRI市场，对控制台的支持微乎其微，这已经导致了大量的系统停机。为了维持和提高用户组的生产力，我们建议用最先进的布鲁克控制台和梯度线圈取代目前的控制台和梯度系统。我们的选择是基于布鲁克控制台和梯度线圈的高性能能力，以及我们在布鲁克系统运营和维护方面的丰富内部经验。新控制台将确保在未来数年内用户群体对各种最先进的磁共振方法的可靠性能，以及先进磁共振方法的持续发展。

 DESCRIPTION (provided by applicant): The Yale MRRC is a pioneer and leading site for using 1H, and 13C MRS and ultra-high resolution fMRI to study metabolism and function in small animal models. The 9.4T 21 cm animal system at the MRRC is the workhorse for these studies since installation in 2004. It presently supports the research of 22 NIH funded faculty at Yale and other institutions including 9 major users. The NIH support for the user group is 25 awards including 2 Center grants (P30, U24) a P01, 18 R01 awards, a DP1 award, an R21, and 2 K awards. It is a major resource for Yale's NINDS P30 MR Core Center and NIDDK Mouse Metabolic Phenotyping Center. However the continued development of novel MR methodology and groundbreaking applications to disease, that have been the hallmark of the research programs on the system, is severely compromised by limitations in its 7 year old Agilent console and 10 year old gradient hardware. Furthermore with the withdrawal of Agilent from the MRI market there is minimal support available for the console which is already leading to substantial system down time. In order to sustain and enhance the productivity of the User group we propose to replace the present console and gradient system with a state of the art Bruker console and gradient coil. Our selection is based upon the high performance capabilities of the Bruker console and gradient coil and our extensive in house experience in operating and maintaining Bruker systems The new console will insure for years to come the reliable performance of a wide range of state of the art MR methods by the User group, and the continued development of advanced MR methods.