Botswana-UPENN Research Consortium of HPV-related Cervical Cancer in HIV Patients

在这份U54申请中，我们建议成立一个跨学科的研究联盟，由加州大学 博茨瓦纳大学(UB)和宾夕法尼亚大学(UPenn)。该财团将专注于多个领域 与一种癌症类型--HIV血清阳性患者中HPV相关性宫颈癌相关的研究 通过大力强调指导和教育，在博茨瓦纳建设研究能力。这个 该联盟将汇集来自宾夕法尼亚大学和宾夕法尼亚大学的经验丰富的调查人员，他们拥有指导方面的专业知识， 研究方法、病毒肿瘤学、癌症治疗学和行为研究。中心研究 该联盟的主题是确定流行病学、发病机制、行为、临床和 HIV血清阳性的HPV相关宫颈癌的免疫危险因素及最佳治疗方案 博茨瓦纳的妇女，可转化为有效的预防和治疗战略 这将降低艾滋病毒相关宫颈癌的负担以及相关的发病率和死亡率。一个 随之而来的主要重点将是通过以下方式在博茨瓦纳发展可持续的研究基础设施 指导和教育。这将是在UB建立与以下相关的独立研究能力的机会 艾滋病毒阳性个体中的癌症。该联盟将为未来更多的平等奠定基础 宾夕法尼亚大学和宾夕法尼亚大学之间的研究伙伴关系。该财团将实现其核心目标，即发展 通过三项研究有效预防和治疗HIV相关性宫颈癌 独一无二的潜在群体。研究围绕三个项目和四个支持核心进行。

In this U54 application, we propose an inter-disciplinary research consortium between the University of Botswana (UB) and The University of Pennsylvania (UPenn). The consortium will focus on multiple areas of study related to one cancer type, HPV-associated cervical cancer in HIV seropositive patients as well as building research capacity in Botswana through a strong emphasis on mentoring and education. The Consortium will bring together experienced investigators from UB and UPenn with expertise in mentoring, research methodology, viral oncology, cancer therapeutics, and behavioral studies. The central research theme of the Consortium is to determine the epidemiology, pathogenesis, behavioral, clinical, and immunological risk factors, and optimal therapeutic approaches of HPV-associated cervical cancer in HIV-seropositive women in Botswana which can be translated into effective prevention and treatment strategies that will lower the burden and associated morbidity and mortality of HIV-associated cervical cancer. An accompanying major focus will be on developing sustained research infrastructure in Botswana through mentoring and education. This will be an opportunity to build independent research capacity at UB related to cancer in HIV-positive individuals. This Consortium will lay the groundwork for additional future equal research partnerships between UB and UPenn. The Consortium will achieve its central goal of developing effective prevention and treatment strategies for HIV-associated cervical cancer through the study of three unique prospective cohorts. Research is organized around three projects and four supporting cores.