Zurich Cohort Study of Young Adults

在过去的一年中，我们继续分析了这项独特的前瞻性队列研究的数据，该研究涵盖了从18岁开始跟踪的年轻人队列的总观察期为30年。我们与苏黎世的同事合作，完成了一项最近发表的分析，描述了成年期精神障碍的发生频率，并考虑了2008年最新一波随访的信息。这是唯一一项描述从年轻人开始的队列中这些模式的研究。分析近似于50岁之前的疾病终身风险。结果表明，精神障碍在这个年龄范围内相对常见;终身风险范围从双相I型障碍的1.21%到重度抑郁症的32.54%。 这些研究结果表明，人们在成年期经历至少一次精神障碍发作是相对常见的，这使我们不禁要问，在一般人群中，有多大比例的成年人在成年期经历反复或慢性精神障碍发作。我们已经开始了一个项目，将在苏黎世队列研究中解决这个问题。苏黎世队列研究的前瞻性、纵向设计使其成为少数几个可以在不依赖于长时间回顾性回忆的情况下研究该问题的数据来源之一。我们将调查特定类别的精神障碍的持续性，包括情绪，焦虑，恐惧症和物质使用障碍，以及一般的精神障碍。我们还将调查在成年期精神障碍的持续性方面的性别差异。 公共卫生影响： 这些研究为了解精神障碍的性质及其在成年人中的负担提供了有价值的见解。苏黎世队列研究是一个非常有价值的数据来源，因为它是最长的以社区为基础的纵向研究，参与者在成年初期入组。关于精神障碍发生频率和持续时间的数据对于规划干预措施和提供服务以及研究病因都很重要。我们对精神障碍的持续性的调查可能会提供一个有价值的对立面，在精神障碍的社区调查中经常报告的高终生患病率。 未来计划： 在接下来的一年里，除了完成上述项目外，我们计划分析以下主题的30年随访数据：1）社区研究中参与者报告的精神障碍患病率和发病年龄的可靠性; 2）成年后身体健康状况和精神障碍的共病性; 3）成年期的睡眠模式以及睡眠与精神障碍之间的关系; 4）一般人群中躁狂、轻躁狂和抑郁的谱，包括发病顺序和不同年龄的模式。

During the past year, we have continued to analyze the data from this unique prospective cohort study that covers a total observation period of 30 years for this cohort of young adults who have been followed since the age of 18. In collaboration with our colleagues in Zurich, we have completed a recently published analysis describing the frequency of occurrence of mental disorders across adulthood, taking into account information from the latest wave of follow-up in 2008. This is the only study that has described these patterns among a cohort starting in young adulthood. Analyses approximate the lifetime risk of disorders through age 50. Results indicate that mental disorders occur relatively commonly across this age range; lifetime risks range from 1.21% for Bipolar I Disorder to 32.54% for Major Depressive Disorder. These findings, that it is relatively common for people to experience at least one episode of mental disorder across the course of adulthood, have led us to ask what proportion of adults in the general population experience repeated or chronic episodes of mental disorder across adulthood. We have begun a project that will address this question in the Zurich Cohort Study. The Zurich Cohort Study's prospective, longitudinal design makes it one of only a few data sources in which this question can be investigated without relying on long periods of retrospective recall. We will investigate the persistence of specific categories of mental disorder, including mood, anxiety, phobias, and substance use disorders, and of mental disorder in general. We will also investigate sex differences in the persistence of mental disorders across adulthood. Public Health Impact: These studies provide valuable insight into the nature of mental disorders and their burden among adults across time. The Zurich Cohort Study is an extremely valuable data source, as it is the longest community-based longitudinal study in which participants were enrolled at the beginning of adulthood. Data on the frequency and persistence of mental disorders are important for planning interventions and service delivery as well as for research on etiology. Our investigation of the persistence of mental disorders may provide a valuable counterpoint to the high lifetime prevalence rates that are often reported in community surveys of mental disorder. Future Plans: During the next year, in addition to completing the project described above, we plan to analyze the 30 year follow-up data on the following topics: 1) the reliability of participant-reported prevalence and age of onset of mental disorders in community-based studies; 2) the comorbidity of physical health conditions and mental disorders across adulthood; 3) patterns of sleep across adulthood and the relationship between sleep and mental disorders; and 4) the spectrum of mania, hypomania, and depression in the general population, including order of onset and patterns across age.