1/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research

综述：马萨诸塞大学波士顿分校和达纳-法伯/哈佛癌症 中心(DF/HCC)于2002年8月启动了他们的伙伴关系。U56期间伙伴关系的最初几年 资助期(2005-2010年)建立了建立 扎实而充满活力的研究合作。展望未来，U54机制在此基础上取得了成果 在研究、能力建设和外联方面开展了一系列强有力的活动。两个关键原则指导着这一持续的 华盛顿大学波士顿分校和明尼苏达大学/明尼阿波利斯大学之间的伙伴关系：a)对解决 癌症发病率、发病率和死亡率方面的种族、民族和社会经济差异问题；以及b)A 相信通过伙伴关系，每个机构都将获得任何一个机构都不能单独实现的好处。 这项续期申请为这些信条的运作方式提供了广泛的证据， 为这两个机构以及这一伙伴关系现在准备实现的方式带来的好处，在 提高水平，癌症控制科学的重大进步。我们建议开展一些活动，以利用 通过跨学科方法了解和解决癌症差异的最新科学 体现了我们“从细胞到社会”的伙伴关系主题。为了支持我们新的凝聚力主题，我们有 提出了三个复杂、竞争激烈的研究项目，涉及基础生物医学的几个领域 和人口科学，将使用证据和方法来汇聚和影响癌症和 多层次分析的癌症健康差异。为了阐明新的研究机会领域， 合作伙伴关系兴奋地探索以生物学为基础的科学和社会/行为之间的交叉 科学。该伙伴关系的当务之急是：1)继续建设生物医学和 华盛顿大学波士顿分校的癌症研究和DF/HCC的癌症差异研究；2)增强和扩大 学生的研究经验，特别关注代表不足的少数族裔(URM)，横跨 整个教育渠道--从本科生到博士后(见研究教育核心)；3) 继续密切指导早期调查人员，重点是研究和职业发展；4) 建立一个强大和强大的外联核心，从传播和发展中汲取科学的状态 执行科学(D&I)，用于建立伙伴关系、转化知识和监测以下方面的成果 在社区组织中建立和维持能力的翻译工作(见外联 核心)；5)通过两个服务核心向U54调查人员提供基础设施支持，包括 研究设计和分析以及基因组学核心(见共享资源核心)；以及6)确保 通过专门的规划和执行，实现项目、核心和研究教育方案的可持续性 赠款与美国国立卫生研究院--机制、基金会支持和/或机构支持相匹配。

Summary: The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) initiated their Partnership in August 2002. The early years of the Partnership during the U56 funding period (2005-2010) established the foundational support and scientific leadership needed to build a solid and vibrant research collaboration. Moving forward, the U54 mechanism drew on this foundation resulting in a robust set of activities in research, capacity building and outreach. Two key tenets guide this sustained partnership between UMass Boston and DF/HCC: a) A common and intense interest in addressing the problem of racial, ethnic, and socioeconomic disparities in cancer incidence, morbidity, and mortality; and b) A belief that through the Partnership, each institution will achieve benefits that neither could achieve on its own. This application for renewal provides extensive evidence of the ways these tenets have been operationalized, the resulting benefits for both institutions and the ways in which this Partnership is now poised to make, at an elevated level, significant advances to the science of cancer control. We are proposing activities that draw on the latest science to understand and address cancer disparities through a transdisciplinary approach that embodies our Partnership theme of “Cells to Society.” In support of our new cohesive theme, we have proposed three sophisticated, highly competitive research projects across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. To elucidate new areas of research opportunity, the Partnership is excited to explore the intersection between biology-based sciences and social/behavioral sciences. The immediate priorities of the Partnership are: 1) Continuing capacity building for biomedical and cancer research at UMass Boston and cancer disparities research at DF/HCC; 2) Enhancing and scaling up research experiences for students with a specific focus on underrepresented minorities (URMs), across the entire educational pipeline –from undergraduate to postdoctoral levels (see Research Education Core); 3) Continuing close mentoring of early stage investigators with a focus on research and career development; 4) Building a strong and robust Outreach Core that draws on the state of the science from dissemination and implementation sciences (D&I) for building partnerships, translating knowledge and monitoring the results of the translation efforts to build and sustain capacity among community-based organizations (see Outreach Core); 5) Offering infrastructural support to U54 investigators through two service cores, including the Research Design and Analysis, and Genomics Cores (see Shared Resource Core); and 6) Ensuring sustainability for projects, Cores and research education programs via dedicated planning and execution of grant matching with NIH-mechanisms, foundation support and/or institutional support.