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中文摘要
翻译
项目总结 波多黎各儿童早期接触和发展研究中心(CRECE)将研究 环境暴露和修饰因素混合对胎儿和儿童早期健康的影响 在这一未得到充分服务、高度暴露的人群中的发展。CREE将利用正在进行的NIH资助的 波多黎各的“保护”怀孕队列研究(P42ES017198)跟踪了1800名孕妇 该岛北部海岸污染严重。在这个丰富的数据集的基础上,CRECE跨学科 来自东北大学、密歇根大学和波多黎各大学的研究小组将 600例围产期暴露儿的早期生活暴露与儿童发育分析 被记录在保护研究中,将他们的研究延长到四岁。CRECE包括三个 研究项目、人类学科服务核心、社区推广和翻译核心以及 管理核心。 社区外联和翻译核心(COTC)将成为CRECE的公共接口。商贸联委会将: 1)确保向参与者反馈高质量的个人数据,并将数据聚合到社区 与人类学科核心和项目调查人员合作。2)发展环境健康 波多黎各的外联和教育方案,并通过以下途径倡导儿童的环境健康 与州和联邦机构以及非政府组织建立伙伴关系;这将在#年完成 与行政核心和项目调查员合作。3)建立和扩大与 医学界和公共卫生界,促进大学间的伙伴关系,倡导公共卫生 倡议,协调学习机会,旨在建设医疗保健专业人员和 负责环境公共卫生活动的公共卫生人员;这将与卫生署合作完成 专家。4)让职业发展学院参与外联和研究,该学院也是COTC的成员 翻译活动。
英文摘要
PROJECT SUMMARY The Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) will study the impact of a mixture of environmental exposures and modifying factors on fetal and early childhood health and development in this under-served, highly-exposed population. CRECE will leverage an ongoing NIH-funded “PROTECT” pregnancy cohort study in Puerto Rico (P42ES017198) that is tracking 1800 pregnant women on the island’s heavily contaminated northern coast. Building on this rich dataset, the CRECE interdisciplinary research team from Northeastern University, University of Michigan, and the University of Puerto Rico will analyze the early life exposure and child development for a cohort of 600 children whose prenatal exposures were documented in the PROTECT study, extending their study through age four. CRECE includes three research projects, a Human Subjects service Core, a Community Outreach and Translation Core and the Administrative Core. The Community Outreach and Translation Core (COTC) will be the public interface for CRECE. The COTC will: 1) Ensure high quality report-back of individual data to participants, and aggregate data to communities, in collaboration with the Human Subjects Core and the project investigators. 2) Develop environmental health outreach and education programs for Puerto Rico and advocate for children’s environmental health through partnerships with state and federal agencies and non-governmental organizations; this will be done in collaboration with the Administrative Core and Project Investigators. 3) Establish and expand relationships with medical and public health communities, facilitate inter-university partnerships, advocate for public health initiatives, and coordinate learning opportunities aimed at building capacity among healthcare professionals and public health staff for environmental public health activities; this will be done in collaboration with the Health Specialist. 4) Involve the Career Development Faculty, also a member of the COTC, in outreach and research translation activities.
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Per- and Polyfluoroalkyl Substances: Second National Conference
  • 批准号:
    9762484
  • 项目类别:
  • 资助金额:
    $3.5万
  • 财政年份:
    2019
  • 负责人:
    Philip M Brown
  • 依托单位:
Assessment of pediatric immunotoxicity, public education, and capacity-building in communities impacted by PFAS-contaminated drinking water
  • 批准号:
    10436901
  • 项目类别:
  • 资助金额:
    $51.5万
  • 财政年份:
    2018
  • 负责人:
    Philip M Brown
  • 依托单位:
Assessment of pediatric immunotoxicity, public education, and capacity-building in communities impacted by PFAS-contaminated drinking water
  • 批准号:
    10215529
  • 项目类别:
  • 资助金额:
    $51.24万
  • 财政年份:
    2018
  • 负责人:
    Philip M Brown
  • 依托单位:
Social Science-Environmental Health Interdisciplinary Collaborations
  • 批准号:
    8836780
  • 项目类别:
  • 资助金额:
    $2.0万
  • 财政年份:
    2014
  • 负责人:
    Philip M Brown
  • 依托单位:
国内基金
海外基金
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
  • 依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    雷芬芳
  • 依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
    --
  • 项目类别:
    面上项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    万荣
  • 依托单位: