Factors influencing change in 24 hour urine composition

描述（由申请人提供）：本K24奖申请旨在提供支持，使加里·柯汉博士能够继续他对指导初级研究者的热情，并扩大他在临床研究方面的工作。他的研究重点是通过调查科学和临床上的重要问题和探索可改变因素的作用来预防常见疾病，主要是在肾脏病学和泌尿学领域。他的长期目标仍然集中在检查和挑战现有的信念和普遍接受的做法，以激励临床实践和理解的重要变化，以改善个人的健康目标。目前，他是NIH资助的研究的主要研究者或共同研究者，研究各种疾病的风险因素，包括肾结石、高血压、心血管疾病和痛风。他正在钱宁实验室的大型队列研究中研究饮食，生活方式因素，遗传贡献和生物标志物。Curhan博士指导了超过25个人，他们都是在学术环境中。他目前是4名获得K奖的初级肾脏病学家和4名由NIH培训赠款支持的肾脏病研究员的主要导师。他积极参与教学和指导教学硕士学位课程。新学员培训的核心将是一个有指导的研究项目。此外，培训将包括在哈佛公共卫生学院的教学课程工作、负责任地进行研究的培训、编写手稿和赠款以及在一个令人振奋和充满活力的研究环境中进行正式介绍。该奖项将支持绝经对24小时尿液成分影响的研究，有助于了解各种常见疾病，包括肾结石和骨质疏松症。学员将直接受益于他们参与这个项目和多个相关的正在进行的项目博士。通过这个K24奖的支持，Curhan博士将继续指导那些希望从事临床研究的人，特别是那些对肾脏病学和泌尿学感兴趣的人。这些人将为我们了解疾病和改善公众健康做出重要贡献。

DESCRIPTION (provided by applicant): This application for a K24 award is to provide support to allow Dr. Gary Curhan to pursue his passion for mentoring junior investigators and to expand his work in clinical investigation. His research focuses on the prevention of common diseases by investigating scientifically and clinically important questions and exploring the role of modifiable factors, chiefly in the areas of nephrology and urology. His long-term objectives remain focused on examining and challenging existing beliefs and commonly accepted practices, with the goal of motivating important changes in clinical practice and understanding to improve the health of individuals. Currently, he is the principal investigator or co-investigator of NIH-funded studies examining risk factors for a variety of conditions including nephrolithiasis, hypertension, cardiovascular disease and gout. He is studying dietary, lifestyle factors, genetic contributions and biomarkers in large cohort studies based at the Channing Laboratory. Dr. Curhan has mentored over 25 individuals, all of whom are in academic settings. He is currently the primary mentor for 4 junior faculty nephrologists with K-awards and 4 nephrology fellows supported by NIH training grants. He is actively involved in teaching and mentoring in didactic Masters degree programs. The centerpiece of training of new mentees will be a mentored research project. In addition, the training will include didactic course work at the Harvard School of Public Health, training in the responsible conduct of research, the preparation of manuscripts and grants, and formal presentations in a stimulating and vibrant research environment. The award will support an examination of the impact of menopause on 24 hour urine composition, contributing to the understanding of a variety of common conditions including nephrolithiasis and osteoporosis. Trainees will directly benefit by their involvement in this project and the multiple related ongoing projects of Dr. Curhan. Support by this K24 award will allow Dr. Curhan to continue to mentor individuals who wish to pursue careers in clinical investigation, particularly those interested in nephrology and urology. These individuals will make important contributions to our understanding of disease and to improving the public's health.