K07 Leadership Grant

描述（由申请人提供）：每年有超过250万的美国老年人患有谵妄（急性精神错乱状态），这是一种常见而严重的老年综合征，相关死亡率为25-33%，随后一年的医疗保健支出为1000亿美元。然而，这些病例中只有不到30%得到确认，而得到证实的预防性干预措施的病例就更少了。治疗和预防谵妄的临床护理是有缺陷的，既因为缺乏经验证据，也因为现有证据没有始终如一地以有效的方式转化。候选人Inouye博士是一位老年病专家和经验丰富的临床研究者，他开展了开创性的工作，促进了我们对谵妄的诊断、危险因素、预后和干预措施的理解。对于这个K07领导奖，她建议发展全国第一个专门关注老年人谵妄的项目，“老年谵妄卓越中心：研究，培训和教育增强（CEDARTREE）”，以推进谵妄的研究和培训。她将在哈佛医学院-希伯来康复中心建立这个项目，汇集世界知名的临床转化研究、老年病学/老年学资源，以及一流的跨学科专业知识和资源来支持这个项目，这将刺激整个大波士顿学术界的研究。具体目标是：1)在谵妄研究中创建一个全面的跨学科培训和指导计划，包括正式的教学课程，研讨会系列，协作工作组和有经验的研究者的个性化指导；2)开发核心资源，吸引跨学科研究者参与与谵妄相关的合作研究（例如，网站研究开发资助，获取新的研究技术和数据库，研究者列表服务，统计/方法学专业知识，谵妄参考书目）；3)到

DESCRIPTION (provided by applicant): Over 2.5 million older Americans develop delirium (acute confusional state) each year, a common and serious geriatric syndrome, with associated mortality rates of 25-33% and accounting for >$100 billion in healthcare expenditures in the ensuing year. Yet, less than 30% of these cases are recognized, and even fewer receive proven preventive interventions. Clinical care to address and prevent delirium is deficient both because empirical evidence is lacking and because existing evidence is not consistently translated in an effective manner. The Candidate, Dr. Inouye, is an expert geriatrician and experienced clinical investigator, who has conducted ground-breaking work to advance our understanding of the diagnosis, risk factors, prognosis, and interventions for delirium. For this K07 Leadership Award, she proposes to develop the nation's first program focusing specifically on delirium in older adults, the "Center of Excellence for Delirium in Aging: Research, Training and Educational Enhancement (CEDARTREE)" to advance delirium research and training. She will establish this program at Harvard Medical School-Hebrew Rehabilitation Center, bringing together world-renowned resources in clinical-translational research, geriatrics/gerontology, and superb interdisciplinary expertise and resources to support the program, which will stimulate research across the greater Boston academic community. The specific aims are to: 1) To create a comprehensive interdisciplinary training and mentorship program in delirium research, including a formal didactic curriculum, seminar series, collaborative working groups, and individualized mentorship with experienced investigators; 2) To develop core resources to attract interdisciplinary investigators to engage in collaborative delirium-related research (e.g., website research development grants, access to novel research technologies and databases, investigator listserve, statistical/methodological expertise, and delirium bibliography); and 3) To serve as a local and national resource for research on delirium in aging through disseminating website resources and educational content, hosting a visiting scholar program, annual scientific symposium, interest groups at national meetings, and developing national linkages to translate evidence. Innovative approaches will be incorporated at every level of the program: translational research on delirium (biomarkers, genomics, advanced neuroimaging), advanced statistical methods to address methodological challenges, and innovative educational strategies (e.g., interactive on-line educational approaches). For Dr. Inouye, the K07 award will provide the opportunity for further career development in key leadership areas and protect time needed to develop, fully implement, evaluate, refine, and establish the self-sustaining infrastructure to assure continuation of the center as an enduring contribution to aging research and training. CEDARTREE represents the first resource of its kind, providing an innovative and much-needed local/national resource and focal point that will enhance the capacity for research on delirium in aging, with the ultimate goal of improving health and quality of life for seniors.