An implantable chronic 128 channel macro and micro ECoG system with integrated recording, stimulation, and impedance measuring capabilities

 描述（由申请人提供）：本提案的目的是设计、开发和验证商业上可行的“人类使用”智能128通道宏观和微观ECoG微系统，该系统具有集成的记录、刺激和阻抗测量功能，用于癫痫监测。微系统包括最先进的微电子信号处理组件，该微电子信号处理组件通过一端上的薄的、高度柔性的、生物兼容的微带状电缆和另一端上的单个经皮柔性电缆（“尾纤”）连接到宏微集成ECoG网格。定制多路复用ASIC电子器件能够以16位分辨率进行128通道记录，并具有快速建立能力（用于刺激选项）和患者 安全电路该组件包含在印刷电路板上，并用聚对二甲苯-C和硅胶封装。封装的微电子元件单元被装入钛盒中，并位于皮肤和颅骨之间的皮下。集成的微系统将具有独特的“雪花”形状的网格设计，其包含交替行的宏通道和微通道。第一阶段的短期目标是在成年绵羊模型中开发、台架测试和验证完整的植入式ECoG微系统，该系统可以在最短的时间内转移到研究和临床实验室。

 DESCRIPTION (provided by applicant): The objective of this proposal is to design, develop, and validate a commercially viable "human-use" smart 128-channel macro & micro ECoG microsystem with integrated recording, stimulation, and impedance measuring capabilities for epilepsy monitoring. The microsystem comprises of a state-of-art microelectronic signal processing component linked to a macro & micro integrated ECoG grid via a thin, highly flexible, bio- compatible micro-ribbon cable on one end and a single percutaneous flexible-cable ("pigtail") on the other end. The custom multiplexing ASIC electronics is capable of 128-channel recordings at 16-bit resolution and has fast settle capability (for stimulation option) and patient safety circuitry. The component is contained on a printed circuit board and is encapsulated with Parylene-C and Silicone. The encapsulated microelectronic component unit is encased in a titanium case and resides subcutaneously between the skin and the skull. The integrated microsystem would have unique "snow-flake" shape grid design containing alternate rows of macro and micro channels. The phase-I would target a short-term goal of developing, bench testing and validating in adult sheep model the complete implantable ECoG microsystem that can be translated to research and clinical lab in the shortest time frame.