Repair after Neonatal Brain Injury

描述(由申请人提供)：这项拨款建议利用先进的成像技术在我们的人类种群中研究大脑发育成熟和网络组织的结构和功能相关性，并在新生啮齿动物中进行类似的相关性研究，重点是定义基本的修复机制。赠款将包括三个项目和两个核心：项目I)新生儿缺血性损伤后的修复--使用结构和代谢系列成像来评估损伤如何改变大脑，在围产期对损伤的反应，以及结构连通性如何与神经发育结果相关。这一队列将包括接受过低温治疗的婴儿。项目II)修复患有先天性心脏病的高危新生儿--在这一高危人群中，大脑发育迟缓。利用结构和代谢成像，我们将确定这种发育障碍是否与大脑连接和功能结果的异常有关。项目III)早产后修复-我们的数据显示，许多早产儿有小脑成熟异常、脑白质发育异常或进行性脑白质疾病合并感染。使用结构和代谢成像，我们将确定连接改变的模式是一致的还是可变的，是否有可能从这些侮辱中恢复，以及连接是永久还是短暂地被这些早期的子宫外生活事件中断。有一个数据管理的行政核心，包括生物统计支助、预算监督、培训和研讨会。成像和神经行为核心(服务核心)将通过确保方法标准化和跟踪不同测试时间点的成像采集来支持三个人体成像项目。此外，这一核心将提供神经行为 在所有的后续访问中进行测试，并将负责跟踪所有项目的患者。

DESCRIPTION (provided by applicant): This grant proposes to study both structural and functional correlates of brain developmental maturation and network organization using advanced imaging techniques in our human populations and similar correlates in newborn rodents with a focus on defining basic mechanisms of repair. The grant will encompass three projects and two cores: Project I) repair after ischemic injury in the term newborn - using both structural and metabolic serial imaging to evaluate how the injuries have altered the brain, its response to injury in the perinatal period, and how structural connectivity relates to neurodevelopmental outcome. This cohort will include babies treated with hypothermia. Project II) repair in high risk newborns with congenital heart disease- there is delayed brain development in this high risk population. Using structural and metabolic imaging, we will determine whether this disorder of development is associated with abnormalities in brain connectivity and functional outcome. Project III) repair after early preterm birth - our data show many preterm infants to have abnormalities of cerebellar maturation, abnormalities of white matter development or progressive white matter disease with infection. Using structural and metabolic imaging, we will determine whether altered patterns of connectivity are consistent or variable, whether recovery from these insults is possible and whether connectivity is permanently or transiently disrupted by these early ex-utero life events. There is an administrative Core for data management including biostatistical support, budgetary oversight, training and seminars. The Imaging and Neurobehavior Core (Services Core) will support the three human imaging projects by ensuring standardization of methods and tracking of imaging acquisition at the various testing time points. In addition, this Core will provide Neurobehavioral testing at all of the follow-up visits, and will be responsible for tracking patients for all projets.