Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)
Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)
批准号:
9471293
负责人:
BARNEY SPARROW
金额:
$167.03万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-04-15 至 2018-04-14
中文摘要
本项目的目的是评估吸入接触c9 -烷基苯(包括1,2,4-三甲苯和2-乙基甲苯)后的毒性。为期三个月的1,2,4-三甲基苯研究处于病理/报告阶段。2-乙基甲苯的2周研究已获批准,并将用于设计3个月的研究。人类很可能同样通过吸入接触到这些化合物。这些亚慢性研究将提供有关一般毒性以及生殖和神经毒性的宝贵数据,并将有助于设计慢性毒性/致癌性研究。
英文摘要
The goal of this project is to evaluate the toxicity C9-alkylbenzenes, including 1,2,4-trimethylbenzene and a 2-ethyltoluene, following exposure via inhalation. Three-month studies of 1,2,4-trimethylbenzene are in the pathology/reporting phase. 2-week studies of 2-ethyltoluene are approved and will be used to design 3-month studies. Humans are likely to be similarly exposed to these compounds via inhalation. These subchronic studies will provide valuable data on general toxicity as well as reproductive and neurotoxicity and will aid in the design of chronic toxicity/carcinogenicity studies.
Keywords: toxicity, inhalation, vanadium, trimethylbenzene, ethyltoluene.
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