South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling

项目摘要 这种延续更新寻求支持6-10年我们的生物医学研究卓越中心 （COBRE）在氧化剂，氧化还原平衡和应激信号在南卡罗来纳州医科大学 （MUSC）。研究者项目侧重于人类病理学，其中包括许多被认为的优势， MUSC包括癌症、心血管疾病、神经退行性疾病和药物/酒精成瘾， 有药物发现和开发的额外组成部分。在每种情况下， 与氧化应激、氧化还原稳态和应激信号传导有关的疾病为 中心的发展规划。我们计划通过5个项目群进一步开发这些资产 和5个核心，涉及来自4个学科的10名知名科学家，项目主任来自4个 来自两个学院的不同部门。由于需求增加，在我们的选管会的要求下，我们 增加了一个新的核心（分析氧化还原），与现有的设施（蛋白质组学，细胞和分子 成像、生物能量学分析、管理）。COBRE有许多教职员工， 在1-4年获得成功的助学金后毕业，其中大多数人仍然隶属于 程序.五名目标学员的研究项目包括：对靶向蛋白酶体的药物的耐药性， 多发性骨髓瘤，癌症干细胞生长的氧化还原调节，线粒体阴离子通道功能中的ROS， 主动脉瓣狭窄线粒体功能中的ROS和迷走神经刺激中的抗氧化剂 帕金森氏症。指导和职业发展努力也为维持和发展职业提供了关键质量。 通过COBRE促进科学发展和独立研究事业的发展。如同先前的 随着初级教员取得成功，COBRE董事计划在 3和6个人在未来五年内，提供了一个新的调查员干部资格的COBRE 程序.这个COBRE包括跨学院和跨部门的合作，与董事有 在医药学院、霍林斯癌症中心和南卡罗来纳州担任领导职务 治疗发现和发展中心。这包括招聘捐赠的主席， 可以作为导师和实验室空间参与药物发现大楼。在第一阶段，我们 与来自南卡罗来纳州和内布拉斯加大学的COBRE合作，促进教学， 研究合作和技术专长。我们的第二阶段COBRE将继续强调以下方面的努力 初级教师，以扩大和提高他们的研究计划。独立的研究项目和建议， 在氧化应激信号传导方面，成熟的研究者之间进行了强有力的互动，沿着有效的指导 将继续是这次COBRE更新的首要目标。

Project summary This continuation renewal seeks support for years 6-10 for our Center of Biomedical Research Excellence (COBRE) in Oxidants, Redox Balance, and Stress Signaling at the Medical University of South Carolina (MUSC). Investigator projects focus on human pathologies that include many of the perceived strengths of MUSC including, cancer, cardiovascular disease, neurodegenerative disorders and drug/alcohol addiction and have additional components of drug discovery and development. In each instance the interface of these diseases with oxidant stress, redox homeostasis and stress signaling provides the fundamentals for the programmatic development of the Center. We plan to develop these assets further via clusters of 5 projects and 5 Cores involving 10 established scientists from 4 academic disciplines, with project Directors being from 4 different departments from 2 colleges. Because of increased demand and at the behest of our EAC, we have added a new core (Analytical Redox), in concert to the existing facilities (Proteomics, Cell and Molecular Imaging, Bioenergetics Profiling, Administrative). The COBRE has a number of faculty members who have graduated following successful grant awards garnered in years 1-4, most of whom remain affiliated with the program. Research projects for the five target mentees cover: resistance to drugs that target the proteasome in multiple myeloma, redox regulation of cancer stem cell growth, ROS in mitochondrial anion channel functions, ROS in mitochondrial function in aortic valve stenosis and antioxidants in vagus nerve stimulation in Parkinson's disease. Mentoring and career development efforts also provide critical mass in sustaining scientific growth and development of independent research careers through the COBRE. As with the previous period as junior faculty members achieve success, there are plans for the COBRE Directors to recruit between 3 and 6 individuals over the next five years, providing a cadre of new investigators eligible for the COBRE program. This COBRE includes cross-college and inter-department collaborations, with the Directors having leadership roles in the Colleges of Medicine and Pharmacy, the Hollings Cancer Center and South Carolina Center for Therapeutic Discovery and Development. This incorporates the recruitment of endowed chairs that can participate as mentors and laboratory space in the Drug Discovery Building. During Phase I, we have partnered with COBRE's from the University of South Carolina (USC) and Nebraska to foster teaching, research collaborations and technical expertise. Our Phase II COBRE will continue to emphasize the efforts of junior faculty, to expand and sharpen their research programs. Independent research projects and proposals, robust interactions among established investigators in oxidative stress signaling, along with effective mentoring will continue to be the overriding goals for this COBRE renewal.