Core C - Data Management, Biostatistics, and Bioinformatics Core

核心C：数据管理、生物统计和生物信息学核心 核心领导人：谢淑丽 摘要/摘要：数据管理、生物统计学和生物信息学核心C 此处介绍的数据管理、生物统计和生物信息学核心(核心C)是 宾夕法尼亚大学医学院(宾夕法尼亚大学)阿尔茨海默病(AD)核心中心(ADCC)。这个 核心C在这一竞争性续签申请中的目标，由国家 老龄化研究所(NIA)是支持数据管理、统计、生物信息学、数据库和相关 宾夕法尼亚州立大学ADCC调查人员和ADCC飞行员获奖者的计算需求。Core C提供的服务 包括：(A)支持数据表格/调查表设计和开发、数据库开发和 管理、数据输入、数据库审核跟踪、数据库安全性、数据库备份和严格的数据质量 控制程序；(B)为宾夕法尼亚反兴奋剂中心的所有活动提供计算和编程支持，包括 实施和整合数据管理和数据管理所需的硬件和软件升级 宾夕法尼亚反兴奋剂中心核心计算系统的研究、例行和档案非现场备份，(C) 从开始到出版的所有研究方面的生物统计学支持，包括研究设计的发展， 进行样本大小和功率计算，并对ADCC数据进行分析，(D)提供 对受训人员进行统计培训，(E)促进宾夕法尼亚州立大学发展中心之间的有效工作关系， NIA资助的其他AD中心(ADDC)和国家阿尔茨海默氏症协调中心(NACC)。因此，核心C 在宾夕法尼亚大学ADCC中扮演着重要和重要的角色，这对AD及其相关研究至关重要 由宾夕法尼亚大学ADCC进行的精神障碍、轻度认知障碍(MCI)受试者和正常对照组(NC) 调查人员及其在其他发展中心的合作者以及继续有效的工作 与NACC的关系。

Core C: Data Management, Biostatistics, and Bioinformatics Core Core Leader: Sharon X. Xie Summary/Abstract: Data Management, Biostatistics, and Bioinformatics Core C The Data Management, Biostatistics, and Bioinformatics Core (Core C) described here is an integral part of the University of Pennsylvania School of Medicine (Penn) Alzheimer's Disease (AD) Core Center (ADCC). The goal of Core C in this competing renewal application for continued funding of the Penn ADCC by the National Institute of Aging (NIA) is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn ADCC investigators and ADCC Pilot awardees. The services provided by Core C include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn ADCC activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Penn ADCC, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the ADCC data, (d) provide statistical training to ADCC trainees, (e) promoting an effective working relationship between the Penn ADCC, other NIA funded AD Centers (ADCs) and the National Alzheimer's Coordinating Center (NACC). Thus, Core C plays an important and significant role in the Penn ADCC that is critical to research on AD and related disorders, subjects with mild cognitive impairment (MCI) and normal controls (NC) conducted by Penn ADCC investigators and their collaborators at other ADCs as well as to the continuation of an effective working relationship with NACC.