Biostatistics and Data Management Core

生物统计与数据管理核心：项目摘要/摘要 这里的生物统计和数据管理核心(核心E)提案是计划项目拨款(PPG)的一部分。 在阐明遗传性和散发性额颞部脑变性机制中的应用 痴呆(FTD)或额颞叶变性(FTLD)。该核心支持所有数据管理， 统计和计算需求，以及维护所有岩心研究数据的PPG数据库 和这个PPG内的1-4个项目。提供的服务包括：(A)支持数据表单设计和 开发、数据库开发和管理、数据库审计跟踪、数据库安全、数据库 备份和严格的数据质量控制程序；(B)为所有PPG提供计算和编程支持 活动，包括实施和整合数据所需的硬件和软件升级 管理和研究，以及对核心计算系统进行日常和存档的异地备份 PPG，包括PPG数据库；(C)从开始到出版对所有研究方面的生物统计支持， 包括研究设计的开发，进行样本量和功率计算，以及执行 对PPG数据的分析；以及(D)在需要时开发新的统计方法以进行数据分析。 因此，核心E对研究的进展和进行起着至关重要的作用 在这个PPG中的研究。本核心建议的研究与补充研究结合在一起 在其他3个核心和本PPG的所有4个项目中进行的调查将有助于更好地了解 FTLD背后的神经退行性机制，特别是FTLD-Tau，可能会加强努力 为这些疾病制定更好的诊断和治疗干预措施。

BIOSTATISTICS & DATA MANAGEMENT CORE: Project Summary/Abstract The Biostatistics and Data Management Core (Core E) proposal here is part of a Program Project Grant (PPG) application to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementias (FTD) or frontotemporal lobar degeneration (FTLD). This core supports all data management, statistical, and computing needs, as well as maintains the PPG database for data from studies for all Cores and Projects 1-4 within this PPG. The provided services include: (a) support for data form design and development, database development and management, database audit trail, database security, database backup, and stringent data quality control procedures; (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, as well as routine and archival off-site backup of computing systems central to the PPG, including the PPG database; (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of PPG data; and (d) development of new statistical methodologies where needed for data analysis. Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in this PPG. The studies proposed in this Core taken together with the complementary studies conducted in the other 3 Cores and all 4 Projects in this PPG will lead to a better understanding of the neurodegenerative mechanisms underlying FTLD, especially FTLD-Tau, which is likely to enhance efforts to develop better diagnostics and therapeutic interventions for these disorders.