Maternal-Fetal Cross Talk: Harmony vs. Conflict

摘要 请求支持一个题为母胎相声：和谐VS. 冲突，由杰夫·默里博士、路易斯·J·穆格里亚博士和尤尔·萨多夫斯基博士组织。会议将在#年举行 2017年10月4日至8日在华盛顿特区举行。母子之间的相互作用 正常妊娠的进展涉及到改善母体健康的因素之间的权衡，甚至冲突。 健康和那些支持胎儿发育和成长的因素。这些可能导致选择性进化。 压力因物种不同而不同，并导致繁殖策略上有趣的差异，从而增强 母胎生物和谐，缓解冲突。平衡这些压力的策略包括 印记，与胎盘重合。不良妊娠结局，如流产、早产、 先兆子痫和宫内发育受限是不同的，在理解如何 母体和胎儿适应之间的不平衡导致了这些紊乱。这次会议的目标是 将来自不同学科的研究人员聚集在一起，他们调查形成母婴因素的 通过探索这些系统是如何协同工作或相互冲突来实现妊娠结局的。这次会议的目标是 发展这些概念，阐明发育、基因组/表观基因组、免疫、微生物和代谢 因素以及考虑怀孕期间的急性暴露，如感染，如何塑造母婴 结果。了解这些考虑的生物学基础将有助于更好的诊断， 孕期治疗和疾病预防。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Maternal-Fetal Cross Talk: Harmony vs. Conflict, organized by Drs. Jeff Murray, Louis J. Muglia and Yoel Sadovsky. The conference will be held in Washington, D.C. from October 4-8, 2017. The interactions between the mother and the fetus during the progression of normal pregnancy involve trade-offs, or even conflicts, between factors that improve maternal health and those that support fetal development and growth. These may lead to selective evolutionary pressures that differ among species, and result in intriguing differences in reproductive strategies that enhance maternal-fetal biological harmony, and mitigate conflict. Strategies to balance these pressures include imprinting, coincident with placentation. Adverse pregnancy outcomes, such as miscarriage, preterm birth, preeclampsia and intrauterine growth restriction, are heterogeneous, and gaps remain in understanding how imbalances between maternal and fetal adaptations contribute to these disorders. The goal of this meeting is to bring together investigators from diverse disciplines who investigate maternal and fetal factors that shape pregnancy outcomes by exploring how these systems work together or are at odds. The conference will aim to develop these concepts, illuminating developmental, genomic/epigenomic, immune, microbial and metabolic factors as well as consider how acute exposures during pregnancy, such as infection, shape maternal-fetal outcomes. Understanding the biology underpinning these considerations will contribute to better diagnosis, treatment and disease prevention during pregnancy.